NCT06864234RecruitingPhase 4
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study
Source: ClinicalTrials.gov · Last updated 14 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA). The main questions it aims to answer are: * Do beta-blockers improve coronary blood flow in patients with ANOCA? * Do beta-blockers reduce coronary microvascular resistance in these patients? Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation. Participants will: * Receive a beta-blocker or a placebo * Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 46 (estimated)
- First submitted
- 2 Mar 2025
- Start date
- 3 Jul 2025
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- VZW Cardiovascular Research Center Aalst
- Diseases
- Coronary artery disease
- NCT number
- NCT06864234
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 46
- From 3 Jul 2025 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Clinical signs or symptoms of congestive heart failure
- Severe valvular heart disease requiring either surgical or percutaneous intervention
- History of coronary artery bypass grafting
- Heart rate \<60 beats per minute
Lab values
- LVEF\<40%
Other
- Tortuous coronary anatomy in which wire manipulation could be complex
- Systolic blood pressure \<100 mmHg
- Unable to give consent
Who the study is looking for
- Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR \>0.80 and no diameter stenosis \>50%
- Normal, TIMI 3 flow at angiography
- Stable haemodynamics
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| OLV Cardiovascular Center Aalst Coordinator of this site? Confirm its status | Aalst | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.