NCT06868797Recruiting
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
Source: ClinicalTrials.gov · Last updated 11 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Heart failure affects 1 to 2% of the adult population in developed countries, representing about 55 million people worldwide. Advanced heart failure is a condition where the heart can no longer provide sufficient cardiac output or equilibrate pressures within its chambers, leading to symptoms such as shortness of breath, fatigue, and water and salt retention. Heart failure affects the kidneys by reducing blood flow directed to them, sometimes leading to kidney congestion. In the long term, this can degrade kidney function. Common medications used to treat heart failure, such as diuretics, can sometimes worsen kidney failure. This link between the heart and the kidneys is known as cardio-renal syndrome and requires careful management of both organs to prevent mutual degradation. Dapagliflozin is an SGLT2 inhibitor medication used to treat type 2 diabetes, heart failure, and certain kidney diseases. It helps reduce blood sugar, improve heart and kidney function, while promoting the elimination of excess salt and water. However, there are limited data regarding the progression of cardio-renal interactions in patients with advanced heart failure. Yet, advanced heart failure is often associated with kidney dysfunction. The protein called suPAR is found in the blood of patients developing kidney disease and/or during the onset of acute kidney injury. This protein will allow to characterize a population of patients with advanced heart failure receiving optimized medical treatment, including dapagliflozin. The main objective of this research is to assess, based on the suPAR protein level in the blood, the progression of cardio-renal damage between inclusion and 6 months in patients with advanced heart failure who are listed for a heart transplant and treated with a therapy including dapagliflozin. The study plans 5 visits over 12 months. The research will take place in the cardiology department of several French hospitals.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 103 (estimated)
- First submitted
- 17 Feb 2025
- Start date
- 29 Aug 2025
- Primary completion date
- 28 Feb 2027
- Lead sponsor
- Central Hospital, Nancy, France
- Diseases
- Heart failure
- NCT number
- NCT06868797
What you commit to
- Study type: Interventional
- Planned participants: 103
- From 29 Aug 2025 to the primary completion date, 28 Feb 2027
- 11 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current acute decompensated HF or hospitalization due to decompensated HF \<30 days prior to the enrolment.
- History of any organ transplant or prior implantation of a ventricular assistance device (VAD) or similar device, or implantation expected after inclusion.
Other illness
- Priority patient on waiting list for heart transplantation.
- Etiology of heart failure due to or associated with uncorrected thyroid disease, obstructive cardiomyopathy, pericardial disease, amyloidosis or restrictive cardiomyopathy.
- Any recent interventional procedure likely to improve symptoms and heart failure status (coronary revascularization, percutaneous mitral valve intervention, cardiac resynchronization therapy) \< 60 days.
- Unstable or rapidly progressing renal disease (autosomal dominant or autosomal recessive polycystic kidney disease, lupus nephritis or ANCA-associated vasculitis).
- Type 1 diabetes mellitus.
- Any condition other than heart failure that could limit survival to less than 12 months.
Other
- Inotrope dependent, existence of ongoing mechanical circulatory support
- Glomerular filtration rate \<25 ml/min/1.73 m2, according to CKD-EPI formula
- Participation in another clinical interventional trial.
- Pregnant women or breastfeeding mothers
- vulnerable persons (guardianship, curatorship, safeguard of justice)
Who the study is looking for
- Age ≥ 18 years and ≤ 85 years
- NYHA class ≥3
- LVEF ≤ 35%
- On GDMT (including dapagliflozin) based on current heart failure practice guidelines at maximal tolerated dose
- On waiting list (or on the registration pathway) for heart transplantation after multidisciplinary Heart Team decision, with anticipated access to heart transplant ≥ 6 months or in a pre-transplant pathway.
- Person affiliated to a social security scheme or beneficiary of such a scheme.
- A person who has received full information about the organization of the clinical research and has signed an informed consent form.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (11)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospice Civil de Lyon - Hôpital Louis PRADEL Coordinator of this site? Confirm its status | Bron | France | Not yet recruiting |
| CHU Grenoble Coordinator of this site? Confirm its status | La Tronche | France | Not yet recruiting |
| CHU Montpellier Coordinator of this site? Confirm its status | Montpellier | France | Not yet recruiting |
| CHU Nantes Coordinator of this site? Confirm its status | Nantes | France | Not yet recruiting |
| Aphp Hegp Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| CHU Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Not yet recruiting |
| CHU Rennes Coordinator of this site? Confirm its status | Rennes | France | Not yet recruiting |
| CHU Rouen Coordinator of this site? Confirm its status | Rouen | France | Not yet recruiting |
| CHU Strasbourg Coordinator of this site? Confirm its status | Strasbourg | France | Not yet recruiting |
| CHU de Toulouse Coordinator of this site? Confirm its status | Toulouse | France | Not yet recruiting |
| CHRU Nancy Coordinator of this site? Confirm its status | Vandœuvre-lès-Nancy | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.