NCT06875648Completed
Intestinal Flora Differences Between Colorectal Cancer Patients and Healthy Individuals
Intestinal Flora Differences Between Colorectal Cancer Patients and Healthy Individuals: A Case-Control Study
Source: ClinicalTrials.gov · Last updated 18 Mar 2025
Brief summary (registry, in English)
This observational case-control study aims to compare the composition of intestinal microbiota between colorectal cancer (CRC) patients and healthy individuals. Fecal samples from 36 CRC patients and 25 healthy controls were analyzed for bacterial abundance. Results indicate significant differences in beneficial, neutral, and harmful bacterial populations between groups, with CRC patients showing reduced beneficial flora (e.g., Lactobacillus) and increased harmful/neutral flora (e.g., Staphylococcus). Further stratification by cancer stage (I-III) revealed progressive dysbiosis with disease progression.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 61 (actual)
- First submitted
- 10 Mar 2025
- Start date
- 1 Jan 2021
- Primary completion date
- 1 Mar 2025
- Lead sponsor
- Hansung University
- Diseases
- Colorectal cancer
- NCT number
- NCT06875648
What you commit to
- Study type: Observational
- Participants enrolled: 61
- From 1 Jan 2021 to the primary completion date, 1 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of inflammatory bowel disease
- For controls: history of colorectal cancer, polyps, or chronic gastrointestinal diseases
Other
- Recent antibiotic or probiotic use (within 3 months)
- Incomplete medical records
- For controls: abnormal colonoscopy or fecal occult blood test within the past year
Who the study is looking for
- Adults (≥18 years) with histopathologically confirmed colorectal cancer (CRC group)
- Archived fecal sample available from time of CRC diagnosis (prior to treatment)
- Complete clinical records including TNM staging (I-III) for CRC patients
- Age- and gender-matched adults without CRC history (control group)
- Archived fecal sample available from routine health check-ups (control group)
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Central Hospital of Guangdong Provincial Nongken Coordinator of this site? Confirm its status | Zhanjiang | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.