NCT06875765Recruiting
Long-term Longitudinal Imaging of Presynaptic Terminals in PD
Longitudinal Measurement of Synaptic Loss and Cognitive Decline in the Long-term Course of Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 29 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD. STUDY DESIGN: The investigators will re-invite participants (both patients with PD and healthy controls) of a previous longitudinal study (NCT04243304, S61477) to undergo evaluation approximately 7 years after the initial baseline study visit (i.e. on average 10 years since the first motor symptoms). All participants will undergo clinical assessment of motor and non-motor symptoms (including cognitive testing), as well as 11C-UCB-J PET-CT (targeting synaptic density marker SV2A), 18F-FE-PE2I PET-CT (targeting DAT) and brain MRI.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 35 (estimated)
- First submitted
- 7 Mar 2025
- Start date
- 16 Jul 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- Universitaire Ziekenhuizen KU Leuven
- Diseases
- Parkinson disease
- NCT number
- NCT06875765
What you commit to
- Study type: Interventional
- Planned participants: 35
- From 16 Jul 2025 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous participation in other research studies involving ionizing radiation with \> 1 mSv over past 12 months.
Other illness
- Neuropsychiatric diseases (unrelated to PD for PD patients)
- Major internal medical diseases
- History of alcohol or drug abuse
Other
- Relevant abnormalities on MR brain
- Contraindications for MR
- Pregnancy or breastfeeding
Who the study is looking for
- Participation in study S61477 (NCT04243304)
Age in the registry: 30 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.