NCT06877273Active, not recruiting
Improving Cognitive Recovery in Multiple Sclerosis
CIRCuiTS MS: Improving Cognitive Recovery in Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 17 Apr 2026
Brief summary (registry, in English)
This study aims to find out whether an adapted version of an existing cognitive rehabilitation program, CIRCuiTS (https://www.circuitstherapyinfo.com), can be used to improve everyday thinking skills for people with Multiple Sclerosis (MS). People living with MS have worked with the study's researchers to adapt CIRCuiTS to meet their needs. They shared the thinking challenges they experience and suggested changes to the program's content and how it is delivered. This study will test whether this adapted version can be delivered practically to people with MS in a trial setting and explore its potential benefits. The findings will help plan a larger trial testing how effective CIRCuiTS is in helping people with MS. Twenty-four people with MS will take part in this pilot trial. Each person will be randomly assigned to start the program either right away or after a 13-week wait. The therapy program involves up to 36 hours of therapist-led and independent sessions over 12 weeks in which the participant builds thinking skills through developing personal strategies for carrying out digital versions of tasks they find challenging. The practicality of delivering the program to people with MS will be judged based on whether problems arise in the trial, such as not being able to recruit enough people or participants not liking it. To explore its potential benefits, the study will check for improvements in progress toward personal goals, thinking abilities, emotional well-being, chronic tiredness, and daily living skills after the therapy. If delivering CIRCuiTS to people with MS is found to be both practical and acceptable to participants, the findings of this trial will be used to design a larger-scale trial of its effectiveness. Ultimately, the goal of this project is to improve the quality of life of people living with cognitive difficulties related to MS.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 7 Mar 2025
- Start date
- 17 Jul 2025
- Primary completion date
- 15 Sept 2026
- Lead sponsor
- King's College London
- Diseases
- Multiple sclerosis
- NCT number
- NCT06877273
What you commit to
- Study type: Interventional
- Planned participants: 24
- From 17 Jul 2025 to the primary completion date, 15 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who are currently receiving cognitive remediation or a similar intervention.
- Physical disabilities that severely limit the individual's ability to attend therapy sessions or engage with the cognitive tasks (whether in-person or online) may lead to exclusion if suitable adaptations cannot be made.
Other illness
- Individuals with a diagnosis of a psychotic disorder or bipolar disorder.
Other
- Individuals with high levels of depression, indicated by a score greater than 9 on the Patient Health Questionnaire-9 (PHQ-9).
- Individuals with active suicidal ideation, indicated by a score greater than 0 on question 9 of the PHQ-9.
Who the study is looking for
- Participants must have a confirmed diagnosis of Multiple Sclerosis (MS), as verified by a healthcare provider.
- Participants should be in a relatively stable phase of their condition, not experiencing a severe relapse or acute health crisis at the time of the study.
- Participants must have sufficient cognitive abilities to engage in therapy sessions, meaning they can follow instructions and perform the cognitive tasks required during the remediation program.
- Participants must be able to effectively communicate in English, both verbally and in writing, to interact with therapists and complete assessments.
- Participants must be adults aged 18 years or older.
- Participants should have personal experience with cognitive challenges related to MS, such as problems with memory, attention, or problem-solving.
- Participants must be willing and able to commit to attending all therapy sessions over the 12-week period, as well as attending assessments and completing any required homework or independent sessions.
- Participants must provide informed consent, demonstrating that they understand the purpose of the therapy trial and are willing to engage in the course of cognitive remediation.
- Participants must have access to a computer (laptop or desktop) for at least one hour per week during the treatment period (12 weeks).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| King's College London Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
Related publications
- Co-development of a protocol for a randomised controlled feasibility trial of CIRCuiTS™ cognitive remediation therapy for people with multiple sclerosis.Pilot Feasibility Stud · 2026 · PMID 42321924
This page is information, not medical advice. Discuss any trial with your doctor.