NCT06878638Completed
Nitrate - Clopidogrel - Acute Coronary Syndrome
Impact of Intravenous Nitrate Treatment on Antiplatelet Effects of Clopidogrel in Acute Coronary Syndrome Patients: A Pilot Study
Source: ClinicalTrials.gov · Last updated 17 Mar 2025
Brief summary (registry, in English)
This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 20 (actual)
- First submitted
- 5 Mar 2025
- Start date
- 1 Feb 2023
- Primary completion date
- 1 Jan 2024
- Lead sponsor
- Bursa Postgraduate Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT06878638
What you commit to
- Study type: Observational
- Participants enrolled: 20
- From 1 Feb 2023 to the primary completion date, 1 Jan 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- use of narcotic analgesics (e.g., morphine), nitrates and glycoprotein IIb/IIIa inhibitors during hospitalization,
Other illness
- recurrent angina,
- history of coronary artery bypass graft (CABG) surgery,
- active infection,
- uncontrolled hypertension,
- diabetes, cerebrovascular accident, Use P2Y12 inhibitor, proton pump inhibitor, oral anticoagulant, statin, CYP enzyme-inducing or inhibiting drugs at the time of admission,
- active systemic disease (e.g., malignancy, thyroid disorders chronic inflammatory diseases, liver dysfunction),
- allergy to ASA or clopidogrel, coagulopathy,
Lab values
- left ventricular systolic dysfunction (ejection fraction \<50%),
- platelet counts below 100,000/μl and hematocrit levels below 29%, or exceeding 52%.
Other
- Hemodynamically unstable and requiring urgent intervention,
- ST elevation on electrocardiography, atrial fibrillation,
- glomerular filtration rate \<60 mL/min/1.73m2,
Who the study is looking for
- diagnosed with non-STEMI
- Patients aged 18 to 75 years
- positive troponin levels,
- blood pressure above 120/70 mmHg
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bursa Yüksek İhtisas Hastanesi Coordinator of this site? Confirm its status | Bursa | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.