NCT06879951Completed
EVALUATION of GINGIVAL CREVICULAR FLUID and SERUM ASPROSIN LEVELS in OBESE and NORMAL-WEIGHT INDIVIDUALS with PERIODONTITIS
Evaluation of Serum and Gingival Crevicular Fluid Asprosin Levels in Obese and Normal-Weight Patients with Periodontitis
Source: ClinicalTrials.gov · Last updated 17 Mar 2025
Brief summary (registry, in English)
Obesity and periodontitis are chronic inflammatory diseases that share common pathological mechanisms. Asprosin, a novel adipokine discovered in 2016, has not been extensively studied in relation to periodontal tissues. In our study, we investigate the levels of asprosin in both serum and gingival crevicular fluid of patients with obesity and those of normal weight who have periodontitis. Additionally, our research aims to clarify the pathophysiological mechanisms linking periodontitis and obesity by examining local and systemic levels of TNF-α, IL-6, and asprosin, alongside clinical periodontal parameters.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 60 (actual)
- First submitted
- 11 Mar 2025
- Start date
- 8 Aug 2023
- Primary completion date
- 10 Aug 2024
- Lead sponsor
- Gazi University
- Diseases
- Obesity
- NCT number
- NCT06879951
What you commit to
- Study type: Observational
- Participants enrolled: 60
- From 8 Aug 2023 to the primary completion date, 10 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who have received periodontal therapy, any oral decontamination treatment, or antibiotics or steroids in the six months prior to the start of the study.
Other illness
- Individuals with a medical history of radiation or cancer therapy.
Lab values
- Patients with diabetes, defined by:
- Hemoglobin A1c (HbA1c) level greater than 6.5%.
- Fasting blood glucose (FBG) greater than 126 mg/dL.
- An abnormal oral glucose tolerance test (OGTT).
Other
- Individuals who are pregnant or breastfeeding.
- Individuals diagnosed with rheumatoid arthritis or lupus erythematosus.
- Smokers.
Who the study is looking for
- Willingness to participate in the study.
- Weight classification:
- Obese individuals: Body mass index (BMI) of 30 kg/m² or higher.
- Normal-weight individuals: BMI between 18.5 and 24.9 kg/m².
- Periodontal health status:
- Bleeding on probing: less than 10%.
- Periodontal pocket depth: less than 3 mm.
- No sites showing attachment loss or alveolar bone loss on radiographs.
- For individuals with periodontitis:
- At least two non-adjacent teeth must show signs of interdental attachment loss.
- Periodontal pocket depth greater than 3 mm.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gazi University Faculty of Dentistry Coordinator of this site? Confirm its status | Ankara | Türkiye | Unknown status |
Related publications
- Serum and gingival crevicular fluid asprosin levels in obese and normal-weight individuals with and without periodontitis: a cross-sectional study.BMC Oral Health · 2026 · PMID 41942957
This page is information, not medical advice. Discuss any trial with your doctor.