NCT06880510Active, not recruiting
The Locus Coeruleus, Norepinephrine and Cognitive Aging
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagus nerve stimulation to assess the health of the LC and its relation to easily measurable peripheral variables.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 22 Mar 2024
- Start date
- 1 Jun 2025
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Cornell University
- Diseases
- Alzheimer disease
- NCT number
- NCT06880510
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 1 Jun 2025 to the primary completion date, 1 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of street drugs
Other illness
- Serious neurological disorders such as epilepsy
- Cardiac arrhythmias
Other
- Moderate or severe brain injury
- Recent concussion
- Colorblindness
Who the study is looking for
- 18+ years of age
- Able to speak and understand English
- Hearing and vision correctable to normal or near-normal
- Willing and able to use a touchscreen
- Willing and able to use a keyboard and mouse
- Willing and able to undergo a MRI scan at the Cornell MRI Facility lasting approximately 90 minutes.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cornell University Coordinator of this site? Confirm its status | Ithaca | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.