NCT06883214Recruiting
Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application
Deciphering the Functional Role of a Three-miRNA Signature in Glioma: From Molecular Mechanisms to Potential Clinical Application
Source: ClinicalTrials.gov · Last updated 5 Jun 2026
Brief summary (registry, in English)
Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopic expression of the miRNAs identified by us has a negative impact on cell viability, proliferation and apoptosis, but above all on migration and invasion.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 10 (estimated)
- First submitted
- 12 Mar 2025
- Start date
- 17 Jan 2023
- Primary completion date
- 17 Jan 2027
- Lead sponsor
- Regina Elena Cancer Institute
- Diseases
- Childhood cancers
- NCT number
- NCT06883214
What you commit to
- Study type: Observational
- Planned participants: 10
- From 17 Jan 2023 to the primary completion date, 17 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- patients with concomitant other solid tumors;
- no surgical material/tissue available;
Other illness
- metastatic disease;
- HIV seropositivity.
Other
- histological diagnosis of non-glial tumor;
Who the study is looking for
- histological diagnosis of glioma;
- no concomitant primary tumor;
- no metastatic disease;
- availability of surgical material/tissue;
- written informed consent.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Regina Elena National Cancer Institute Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.