Effect of Low Valine Diet on Body Weight and Metabolic Parameters

Prior treatment

• Continuously used drugs that may cause weight changes for more than 2 weeks in the past year (such as glucocorticoids, thyroid hormones, etc.);
• Those who had gastric volume reduction surgery or digestive tract surgery;

Other illness

• Liver diseases caused by other reasons: such as alcoholic liver disease, acute and chronic viral hepatitis, drug-induced, immune hepatitis (AMA, SMA, ANA), cirrhosis, liver cancer, etc.;
• Life expectancy of no more than 3 years in the presence of serious health conditions;
• Those who cannot participate in the follow-up of the intervention due to other conditions;
• Those diagnosed with any tumor disease;

Lab values

• Other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, Cushing's syndrome, etc.;
• Poorly controlled diabetic patients: HbA1c \>9.5% within three months; or use of hypoglycemic drugs that may affect weight, including pioglitazone, GLP-1, SGLT2 inhibitors;
• Chronic kidney disease or severe renal impairment, defined as serum creatinine greater than 2.0mg/dL;
• Serum ALT greater than 3 times the upper limit of normal;

Other

• Excessive drinkers (defined as: in the past 6 months, the weekly alcohol intake of men exceeds 140g, and that of women exceeds 70g);
• Those who plan to get pregnant in the near future;
• Participated in other clinical trials in the past 4 weeks;
• Subjects who participated in strenuous exercise or planned to change their diet structure;
• Unable to sign the informed consent form.

• Male or female, 16 years old ≤ age ≤ 80 years old;
• BMI ≥ 24kg/m2