NCT06886477Completed
Sickle Cell, Pain and Mediterranean Diet
Exploring the Mediterranean Diet as A Promising Approach for Alleviating Chronic Pain in Sickle Cell Disease
Source: ClinicalTrials.gov · Last updated 13 Jul 2026
Brief summary (registry, in English)
The goal of this study is to compare pain levels in individuals with Sickle Cell Disease while following the Mediterranean Diet to pain levels while following their usual diet.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 37 (actual)
- First submitted
- 11 Mar 2025
- Start date
- 1 May 2025
- Primary completion date
- 9 Jul 2026
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Sickle cell disease
- NCT number
- NCT06886477
What you commit to
- Study type: Interventional
- Participants enrolled: 37
- From 1 May 2025 to the primary completion date, 9 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Having taken systemic antimicrobials (to treat an infection in the previous 4 weeks)
- Currently receiving dialysis treatment
Other illness
- History of colon cancer or inflammatory bowel disease (given potential untoward effects on the gut microbiome)
- History of Clostridium difficile infection in the preceding 12 weeks;
- Currently following a Mediterranean diet, vegan diet, or dietary restrictions (e.g., religious, food intolerance/allergy) that preclude adoption of a Mediterranean diet
Other
- Unable to agree to maintain physical activity at the current level for the duration of the study
- Lack of access to a space to safely store and reheat food items
- Living in a facility that provides meals.
- Pregnancy or breastfeeding
- More than 7 in-patient hospital stays in the last year
Who the study is looking for
- Sickle Cell Disease Diagnosis
- Chronic non-vaso-occlusive pain experienced on average ≥ 3 days per week for \> 6 months (based on a response of "Most days," "Every day," or "Some days" and not "Never" to the question "In the past 6 months, how often have you had pain?")
- Ability to speak, read, write, and understand English
- A Mediterranean Eating Pattern for Americans (MEPA-III) score \<13, indicating that they do not follow a Mediterranean diet.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Illinois Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.