NCT06887075Not yet recruiting
Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation
Source: ClinicalTrials.gov · Last updated 20 Mar 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Kidney transplantation (KT) benefit-risk ratio assessment is a challenge in a growing population of older patients with end-stage kidney disease. A pre-KT frailty phenotype has been found predictive of post-KT complications, but biological mechanisms of frailty are poorly known is these patients. Frailty is associated with chronic low-grade inflammation in the older general population, possibly through the inflammasome pathway. Our main objective is to assess if systemic activation of inflammasomes is associated with frailty in older candidates to KT.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 22 Jan 2025
- Start date
- 15 Apr 2025
- Primary completion date
- 15 Feb 2027
- Lead sponsor
- University Hospital, Bordeaux
- Diseases
- Chronic kidney disease
- NCT number
- NCT06887075
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 15 Apr 2025 to the primary completion date, 15 Feb 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Inclusion criteria:
- Age ≥ 70
- Patient candidate to kidney transplantation (during assessment for inscription on the waiting-list, or during waiting time after effective inscription), without absolute contraindication
- Free, informed and written consent signed by the participant and the investigator (at the latest, on the day of inclusion and before any examination required by the research).
- Person affiliated or beneficiary of a social security scheme
- Exclusion criteria:
- Inclusion in an industrial study refusing co-inclusion in our study
- Person under guardianship, assisted decision-making or under temporary guardianship
Age in the registry: 70 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Bordeaux - Hôpital Pellegrin Coordinator of this site? Confirm its status | Bordeaux | France | Unknown status |
| CHU de Bordeaux, Hôpital Xavier Arnozan- Gérontologie Clinique Coordinator of this site? Confirm its status | Pessac | France | Unknown status |
| CHU de Toulouse - Hopital Rangueil Coordinator of this site? Confirm its status | Toulouse | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.