NCT06889415Completed
Rheumatoid Arthritis and Osteosarcopenia: Associated Factors
The Frequency of Osteosarcopenia in Patients With Rheumatoid Arthritis and the Factors Affecting the Sarcopenia-osteoporosis Relationship
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Brief summary (registry, in English)
Our study is a cross-sectional study, and its aim is to compare and analyze the prevalence of sarcopenia and osteoporosis in patients with rheumatoid arthritis (RA) with a control group and to reveal the impact of sarcopenia on osteoporosis, fall risk, and fracture risk. This prospective cross-sectional study will include 100 rheumatoid arthritis patients and 100 healthy controls, matched for age and sex. Patients will be consecutively and meticulously enrolled based on inclusion and exclusion criteria. A detailed medical history and examination will be performed on the patients, and their clinical and sociodemographic characteristics will be recorded. Blood tests for RA (RF, Anti-Cyclic Citrullinated Peptide (anti-CCP), CRP, ESR) and disease activity levels (DAS28) will be recorded. The prevalence of osteosarcopenia will be assessed in both the RA and healthy control groups.These groups will be evaluated using various scales and tests (including power, performance tests) including musculoskeletal ultrasonographic measurements and clinical functional assessment tests. he sarcopenic group will be categorized based on the level of sarcopenia, according to the new ISarcoPRM criteria (non-sarcopenic, dynapenic, sarcopenic, and severe sarcopenic). Osteosarcopenia will be evaluated for both groups, and the collected data will be analyzed with primary and secondary outcomes. The analysis will explore the potential relationships between rheumatoid inflammation, sarcopenia, and osteoporosis.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 201 (actual)
- First submitted
- 3 Mar 2025
- Start date
- 15 Aug 2023
- Primary completion date
- 30 Nov 2025
- Lead sponsor
- Konya Beyhekim Training and Research Hospital
- Diseases
- Rheumatoid arthritis, Osteoporosis
- NCT number
- NCT06889415
What you commit to
- Study type: Observational
- Participants enrolled: 201
- From 15 Aug 2023 to the primary completion date, 30 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Having an acute illness/disability or significant cognitive impairment that prevents understanding and performing the required tests
- Having thyroid or parathyroid disease, uncontrolled diabetes, Cushing's syndrome, anemia.
- History of malignancy
- Severe cardiovascular disease, enal failure, advanced-stage COPD, decompensated liver disease
- History of gastrointestinal (GIS) surgery
- 7-Having another coexisting autoimmune/inflammatory rheumatic disease (e.g., SLE, Ankylosing Spondylitis, etc.), psoriatic arthritis, vasculitis, familial Mediterranean fever...)
- 8-Having severe/symptomatic hand osteoarthritis and/or deformities
- 9-Severe/symptomatic osteoarthritis in the knee, lumbar, hip, or ankle region
- 10-Having Carpal Tunnel Syndrome, De Quervain, lateral epicondylitis, cubital tunnel syndrome or a history of traumatic hand injury
- 11-Having a significant neurological disease, stroke, MS, myopathy, Parkinson's disease, radiculopathy/polyneuropathy/brachial plexopathy or others nerve root compressions
- 12-History of surgical intervention on the upper and lower extremities or spine
- 13-Having severe kyphosis or scoliosis
- 14-Having any others disease causing balance disorders (neurological, orthopedic, metabolic, etc.)
- 15-Having a major/significant psychiatric disorder (based on the medical history, and hospital records)
- 16-Current use of androgens or estrogens
- 17-Having prostheses, being fully dependent, or immobilized
Who the study is looking for
- Being diagnosed with RA according to the ACR/EULAR 2010 criteria
- Being a female or male over the age of 50
- Having the mental and physical capacity to complete the study questionnaires and tests
- Providing voluntary consent to participate in the study by signing the Informed Consent Form
Age in the registry: 50 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Konya Beyhekim Training and Research Hospital Physical Medicine and Rehabilitation Clinic Coordinator of this site? Confirm its status | Konya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.