NCT06894121Completed
Comparing Unilateral and Bilateral Proximal GONPRF in Migraine Treatment
Comparison of the Efficacy of Unilateral and Bilateral Proximal Greater Occipital Nerve Pulsed Radiofrequency in the Treatment of Migraine
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
This study is designed to compare the clinical effectiveness of unilateral and bilateral Greater Occipital Nerve Pulsed Radiofrequency (GON-PRF) treatment at the C2 level in patients with migraine. The procedure will be guided by ultrasound and will focus on evaluating how each technique affects migraine symptoms. The main goal of this study is to assess the impact of both unilateral and bilateral GON-PRF treatments on migraine relief. Additionally, the secondary objectives of this study include evaluating the effects of these treatments on migraine-related disability and comparing any potential side effects or complications that may occur during the treatments. This research will help us understand which technique may be more effective and provide more information on the safety of these treatments.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 217 (actual)
- First submitted
- 18 Mar 2025
- Start date
- 18 Dec 2024
- Primary completion date
- 1 Apr 2026
- Lead sponsor
- Ankara City Hospital Bilkent
- Diseases
- Migraine
- NCT number
- NCT06894121
What you commit to
- Study type: Interventional
- Participants enrolled: 217
- From 18 Dec 2024 to the primary completion date, 1 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Interventional migraine treatment within 3 months prior to GON-PRF
- Botulinum toxin injection within 3 months prior to GON-PRF
- Non-pharmacological migraine treatment (e.g., acupuncture, physical therapy, ozone therapy, cognitive behavioral therapy) within 3 months prior to GON-PRF
Other illness
- Headache secondary to comorbid conditions (e.g., uncontrolled hypertension, intracranial lesions)
- Failure to attend follow-up visits
- Development of any condition that meets exclusion criteria during the study
Other
- Diagnosis of primary headache other than migraine according to ICHD-3 criteria
- Fewer than 5 migraine attacks per month
- Withdrawal of consent at any stage of the study
Who the study is looking for
- Age between 18 and 65 years
- Followed at the Algology outpatient clinic of Ankara Bilkent City Hospital
- Diagnosis of episodic migraine (≥5 attacks per month) or chronic migraine according to ICHD-3 criteria
- Inadequate response to migraine preventive medications
- Not currently using preventive migraine medication OR no change in medication and/or dosage within the last 3 months
- No bleeding or coagulation disorders
- No active infection
- Not pregnant and not suspected of pregnancy
- No history of craniocervical surgery affecting the intervention area
- Able to understand the study and provide written informed consent
- Able to comply with study procedures and follow-up
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Health Sciences University, Ankara Bilkent City Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.