NCT06898138Not yet recruiting
Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations
Acute Stimulation for the Modulation of Epileptic Events With a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 8 (estimated)
- First submitted
- 20 Mar 2025
- Start date
- 1 Nov 2026
- Primary completion date
- 15 Feb 2029
- Lead sponsor
- Mayo Clinic
- Diseases
- Epilepsy
- NCT number
- NCT06898138
What you commit to
- Study type: Interventional
- Planned participants: 8
- From 1 Nov 2026 to the primary completion date, 15 Feb 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subjects will be excluded if their condition makes them unable to continue with recordings.
Who the study is looking for
- Patients with medically refractory epilepsy, who have been deemed appropriate candidates for intracranial EEG monitoring
- Adult men and women (18≤ age \<70 years)
- Children (3≤ age \<18 years)
- Includes women and minorities
Age in the registry: 3 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Baylor College of Medicine Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.