NCT06900881RecruitingPhase 2/3
Role of Kefir Mouth Wash in Oral Health Status Amelioration
Role of Kefir Mouth Wash in Oral Health Status Amelioration: An in Vivo Study
Source: ClinicalTrials.gov · Last updated 24 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The present research aims to evaluate the efficiency of kefir mouthwash in enhancing oral health status by employing an in vivo experimental approach. Specifically, the study will assess how kefir mouthwash influences key oral health indicators, including gingival inflammation, plaque development, oral hygiene status, and halitosis. The study will be conducted over a 28-day period, with follow-up assessments every 14 days. The study will include systemically healthy adults with moderate gingivitis. Clinical parameters such as the Gingival Index (GI), Plaque Index (PI), and Simplified Oral Hygiene Index (OHI-S) will be measured, along with inflammatory biomarkers, including Interleukin-1β (IL-1β) and Interleukin-10 (IL-10). Halitosis will be evaluated using a Hali meter device. All of these will be measured at base line and day 14 and day 28 end of the study. Chlorhexidine 0.12% will be used as a comparative control to evaluate the efficacy of kefir mouthwash in improving oral health. This research intends to provide scientific evidence supporting the use of kefir as a probiotic-based mouthwash, offering a natural alternative to chemical mouthwashes and potentially reducing the negative consequences commonly associated with their use.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 9 Mar 2025
- Start date
- 6 Apr 2025
- Primary completion date
- 10 Sept 2025
- Lead sponsor
- Al-Mustansiriyah University
- NCT number
- NCT06900881
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 60
- From 6 Apr 2025 to the primary completion date, 10 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of oral prophylaxis within the last 6 months prior to the study as this can confound the results, making it difficult to determine the real effect of the mouthwash.
Other illness
- History of systemic diseases.
- History of antibiotic therapy in the past 3 months.
- Subjects with deleterious habits such as smoking, because it may affect oral health status, causing periodontal disease, altered oral microbiota, and impaired healing. This can confound the study results, making it difficult to observe the mouthwash effect .
- Failure to follow the prescription regimen.
- Failure to follow the research protocol.
Other
- Pregnant, lactating females.
- Subjects with mouth breathing habits.
- Subjects with orthodontic and prosthodontic appliances.
Who the study is looking for
- Age range 18-28 years.
- Systemically healthy people without a history of chronic illness.
- Those suffering with moderate gingivitis.
- Not using any antibiotics over three months
Age in the registry: 18 years to 28 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Al-Mustansiriyah University/College of Dentistry Coordinator of this site? Confirm its status | Baghdad | Iraq | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.