NCT06904365Completed
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women (OvAR-Y): an In-Silico Feasibility Trial
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
Female patients with early onset (\<50 years old) pelvic malignancies such as uterine and rectal cancers are rising in incidence, which often requires pelvic radiation; many of these patients are premenopausal and at a high risk of premature ovarian failure from radiotherapy. Premature ovarian failure carries significant cardiac, musculoskeletal, sexual, and psychosocial morbidity. Ovarian transposition carries variable success rates, is not readily accessible to the general population, and can still be at risk of clinically significant radiotherapy doses. There is an unmet need for innovative techniques to protect ovarian function.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 11 (actual)
- First submitted
- 24 Mar 2025
- Start date
- 8 Apr 2025
- Primary completion date
- 14 Oct 2026
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Head and neck cancer, Bladder cancer, Cervical cancer, Lung cancer, Colorectal cancer, Liver and biliary tract cancer, Gastric and esophageal cancer, Sarcoma
- NCT number
- NCT06904365
What you commit to
- Study type: Observational
- Participants enrolled: 11
- From 8 Apr 2025 to the primary completion date, 14 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior pelvic radiation
- Prior diagnosis of ovarian insufficiency/failure or menopause
Other illness
- Prior cancer therapies that are known to impact ovarian function
Age
- Clinically peri- or post-menopausal
- For patients \> 45 years old, if there is a clinical history of vasomotor symptoms OR irregular periods, then the patient must be excluded.
- For patients ≤ 45 years old, if there is a history of vasomotor symptoms consistent with menopause OR irregular menstruation for ≥3 months OR recent changes in their menstrual cycle \> 14 days, then the patient must be excluded.
Other
- Surgically removed or transposed ovaries
- Pregnant and/or breastfeeding
Who the study is looking for
- Biologic female
- Age between 18 and 50 years old (inclusive)
- Clinically premenopausal (defined as having active, regular menstruation without vasomotor symptoms)
- At least one of two ovaries readily visualized on diagnostic CT or MR imaging as confirmed by radiologist
- Planning to receive radiation therapy (for any indication)
- Ability to understand and willingness to sign an IRB-approved written informed consent document.
Age in the registry: 18 years to 50 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.