NCT06906276Recruiting
Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
Walking and Thinking - Brain Activity During Complex Walking in Atypical Parkinsonian Syndromes
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as atypical Parkinson's disease (APD) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecologically valid state. The investigators aim therefore to explore brain function during complex walking in healthy and APD by investigating the effects of age and neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in older healthy adults and people with APD.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 12 Mar 2025
- Start date
- 14 Mar 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Karolinska Institutet
- Diseases
- Parkinson disease
- NCT number
- NCT06906276
What you commit to
- Study type: Observational
- Planned participants: 30
- From 14 Mar 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other neurological diseases
- Other diseases that can affect gait or balance.
Other
- cognitive difficulties affecting the ability to understand and/or follow verbal/written - instructions
- severe freezing of gait
- Severe hearing or visual impairments that affect participation in the assessments
Who the study is looking for
- clinical diagnosis of PSP according to Movement Disorder Society (MDS) (2017) or
- MSA according to MDS criteria (2022)
- the ability to walk with or without a mobility device for ≤5 minutes continuously
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Karolinska Institutet Coordinator of this site? Confirm its status | Solna | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.