NCT06907212Enrolling by invitation
Transcriptional Changes in Isolated Human Adipocytes During Obesity
Human Adipocytes - Transcriptional Network Changes Associated With Obesity
Source: ClinicalTrials.gov · Last updated 2 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Adipocytes play an important role in our body through their function as metabolic energy stores in the form of fat deposits, which are stored when metabolic energy is in excess and released when energy levels are low. In severe obesity, adipose tissue grows through the production of more adipocytes from stem cells (hyperplasia) and the increase in the size of existing adipocytes (hypertrophy). This ability of adipocytes, to maintain their functionality during tissue expansion, is critical in determining the development of obesity-related comorbidities. However, not all adipocytes are the same as adipocyte function differs greatly depending on the depot in which they are found. To elucidate the mechanisms underlying adipocyte adaptability, it is necessary to obtain a deep systems biology understanding of how signaling in different types of adipocytes regulates metabolism and function. Currently, this research group is conducting a systems biology analysis of adipocyte plasticity in obesity in mouse models, but adipose tissue biopsies from different depots in humans are lacking and needed to investigate the regulation of adipocyte function and plasticity in humans. Such studies of adipocytes are crucial for the understanding how obesity affects adipose tissue function and leads to comorbidities.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 16 Dec 2024
- Start date
- 1 Apr 2023
- Primary completion date
- 1 Jun 2025
- Lead sponsor
- University of Southern Denmark
- Diseases
- Obesity
- NCT number
- NCT06907212
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Apr 2023 to the primary completion date, 1 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Chronic use of corticosteroids (cortisone)
Other illness
- Active viral hepatitis, HIV positive
- Autoimmune diseases (i.e. lupus)
- Contraindications for biopsy: bleeding tendency.
- Cancer or other comorbidity with an expected survival time of less than 12 months
Other
- Unable to give appropriate consent
Who the study is looking for
- Age \> 18 years old
- BMI\> 19 kg/m2
- Can receive oral and written information and give appropriate consent
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bispebjerg Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.