NCT06909045Recruiting
Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Randomized Controlled Trial Comparing Adaptive Versus Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 29 Jan 2026
Brief summary (registry, in English)
The objective of the CLOSE-PD study is to compare the efficacy of adaptive deep brain stimulation (aDBS) with continue deep brain stimulation (cDBS) in patients with Parkinson's disease. The main question it aims to answer is: \- whether the change in daily mean ON time without troublesome dyskinesia in aDBS is greater than cDBS over a six-month follow-up period? Researchers will compare aDBS to regular continue deep brain stimulation (cDBS). Participants will: * be set up to cDBS during the first programming visit (visit 2); * be randomized 1:1 to aDBS or cDBS two weeks after visit 2; * follow-up will be at three and six months after visit 2; * complete PD Home diary at baseline, two weeks, three months and at six months after visit 2.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 130 (estimated)
- First submitted
- 10 Mar 2025
- Start date
- Jan 2026
- Primary completion date
- Feb 2027
- Lead sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Diseases
- Parkinson disease
- NCT number
- NCT06909045
What you commit to
- Study type: Interventional
- Planned participants: 130
- From Jan 2026 to the primary completion date, Feb 2027
- 4 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Mild cognitive impairment or dementia;
Other
- Legally incompetent adults;
- Patients with ongoing participation in other clinical trials involving neurological interventions;
- Inability to recognize the difference between the motor ON or OFF state;
- Pregnancy.
Who the study is looking for
- Diagnosis of idiopathic PD based on the UK Brain Bank criteria (Hughes et al. 1992);
- Age older than 18 years;
- Previous implantation of Medtronic PerceptTM PC/RC DBS electrodes bilateral targeting the STN;
- Optimal contact point compatible with aDBS in at least one STN;
- Reliable beta peak in at least one STN;
- Able to provide informed consent and comply with the study protocol;
- Understand the Dutch language.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Not yet recruiting |
| Amsterdam UMC Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Maastricht UMC Coordinator of this site? Confirm its status | Maastricht | Netherlands | Not yet recruiting |
| HagaZiekenhuis Coordinator of this site? Confirm its status | The Hague | Netherlands | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.