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NCT06910956Recruiting

Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT

Deep Learning Using Routine Chest X-Rays and Electronic Medical Record Data to Identify High Risk Patients for Lung Cancer Screening CT

Source: ClinicalTrials.gov · Last updated 11 May 2026

Brief summary (registry, in English)

The goal of this clinical trial is to evaluate whether an AI tool that alerts providers to patients at high 6-year risk of lung cancer based on their chest x-ray images will improve lung cancer screening CT participation. The main question it aims to answer is: Does the AI tool improve lung cancer screening CT participation at 6 months after the baseline outpatient visit? The intervention is an alert to the provider to discuss lung cancer screening CT eligibility, for patients considered at high risk of lung cancer based on CXR-LC AI tool. Intervention and non-intervention arms will be compared to determine if lung cancer screening CT participation increases. Individuals who are considered high-risk by the tool, but who do not meet the Medicare/USPSTF pack-year or quit-date lung screening eligibility criteria may be offered research lung screening CT.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
1500 (estimated)
First submitted
28 Mar 2025
Start date
20 May 2025
Primary completion date
1 Jul 2027
Lead sponsor
Massachusetts General Hospital
Diseases
Lung cancer
NCT number
NCT06910956

What you commit to

  • Study type: Interventional
  • Planned participants: 1500
  • From 20 May 2025 to the primary completion date, 1 Jul 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • History or signs/symptoms of lung cancer. Recent (within 2 years) chest CT. Clinical indication for chest CT beyond lung cancer screening.

Criteria the registry did not label

  • Major Inclusion Criteria:
  • Scheduled outpatient appointment with participating provider.
  • 50- to 77-year-old who currently or formerly smoked, to include persons potentially eligible for lung screening based on Medicare guidelines.
  • Recent (within 2 years) PA chest radiograph.

Age in the registry: 50 years to 77 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Massachusetts General Hospital
Coordinator of this site? Confirm its status
BostonUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.