NCT06914726Enrolling by invitation
Patient Centered Clinical Decision Support for Hereditary Cancer Syndromes
Randomized Trial to Improve Care of Patients With Hereditary Cancer Syndromes
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
The goal of this clinical trial is to address care gaps for participants at high risk of breast and ovarian cancer (HBOC), or Lynch syndrome (LS) because of testing positive for specific genetic variants. A patient-centered clinical decision support (PC-CDS) tool will help identify participants with genetic variations and display recommendations for referrals and testing to the clinician and participant at a primary care visit. The main question the study aims to answer is: \- Does clinical decision support for participants with hereditary cancer syndromes improve the use of evidence-based cancer prevention care. Participants being seen in the PC-CDS group are compared to participants being seen in usual care (UC) to see if they are up to date on guideline-based cancer prevention care and to see if participants in the PC-CDS group report more shared decision making and higher rates of self-management of their genetic cancer risks. Participants will be asked to answer survey questions.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 2488 (estimated)
- First submitted
- 31 Mar 2025
- Start date
- 9 Jul 2025
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- HealthPartners Institute
- Diseases
- Ovarian cancer
- NCT number
- NCT06914726
What you commit to
- Study type: Interventional
- Planned participants: 2488
- From 9 Jul 2025 to the primary completion date, 30 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently receiving active treatment for cancer, OR
Other illness
- Diagnosis of dementia, OR
Other
- In long-term care, palliative care, or hospice care.
Who the study is looking for
- Aged 18 years or more at index clinical encounter,
- Existing genetic testing or problem list evidence of HBOC or LS,
- Index clinical encounter is with a PCC (family practice, general internal medicine, nurse practitioner, or physician assistant) at a randomized primary care clinic during the accrual period,
- At the time of the index clinical encounter have EITHER (i) Evidence of having HBOC and not up-to- date on selected variant-specific cancer prevention care OR (ii) Evidence of having LS and not up-to-date on selected variant gene-specific cancer prevention care
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| HealthPartners Medical Group Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.