NCT06916208Recruiting
Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity. In addition to exposure to cold, which is the major physiological inducer of brown adipocytes, it seems that exercise and the intake of "adrenergic" foods can activate the TAB and potentially induce a change from white to brown tissue via the production of adrenalin and myokines. Acute and/or chronic effects of thermogenic food supplements have been reported on BAT activation and energy metabolism. The most conclusive of these involve the capsinoids found in sweet peppers and chillies. Weight loss also improves BAT activation. The BAT has already been identified in children. A decrease in its volume and activity from childhood to adolescence and during puberty has been reported. The main objective of this randomized controlled double-blind study is to investigate the effects of capsinoid dietary supplementation on BAT activity in obese adolescents. Our general working hypothesis is that capsinoid supplementation, combined with dietary management, leads to an increase in BAT activity.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 38 (estimated)
- First submitted
- 21 Mar 2025
- Start date
- 3 Mar 2025
- Primary completion date
- Mar 2027
- Lead sponsor
- University of Avignon
- Diseases
- Obesity
- NCT number
- NCT06916208
What you commit to
- Study type: Interventional
- Planned participants: 38
- From 3 Mar 2025 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- participation in another study or in a period of exclusion determined by a previous study
Other illness
- known allergy to capsinoids and/or soya
- inflammatory digestive pathology and/or history of digestive tract surgery
Other
- pregnant, parturient or breastfeeding
- The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively.
- It proves impossible to provide the adolescent or parental guardian(s) with informed information.
Who the study is looking for
- member or beneficiary of a health insurance scheme
- aged between 11 and 18
- Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months.
- effective contraception (in pubescent females)
Age in the registry: 11 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institut Saint Pierre Coordinator of this site? Confirm its status | Palavas-les-Flots | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.