NCT06917079RecruitingPhase 1
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-11818 in Subjects With Advanced KRAS Mutant Cancers
Source: ClinicalTrials.gov · Last updated 2 Jun 2026
Brief summary (registry, in English)
A first in human study to evaluate the safety and preliminary antitumor activity of BBO-11818, a pan-KRAS inhibitor, in subjects with locally advanced unresectable or metastatic KRAS mutant solid tumors.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 665 (estimated)
- First submitted
- 1 Apr 2025
- Start date
- 31 Mar 2025
- Primary completion date
- Aug 2027
- Lead sponsor
- TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
- Diseases
- Lung cancer, Pancreatic cancer, Colorectal cancer
- NCT number
- NCT06917079
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 665
- From 31 Mar 2025 to the primary completion date, Aug 2027
- 17 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Malignancy within the last 2 years as specified in the protocol
Other
- Untreated brain metastases
- Other inclusion/exclusion criteria are specified in the protocol.
Who the study is looking for
- Histologically documented locally advanced and unresectable or metastatic NSCLC, PDAC, CRC, or other solid tumor with KRAS G12A, G12C, G12D, G12S, or G12V mutation
- Measurable disease by RECIST v1.1
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1
- Life expectancy \>24 weeks
- Adequate organ function
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (17)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peter MacCallum Cancer Centre Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Sarah Cannon Research Institute at Mary Crowley Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| The University of Texas MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| The Angeles Clinic and Research Institute - West Los Angeles Office Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
| Columbia University Irving Medical Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| NYU Langone Health Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| OSF Healthcare Cancer Institute Coordinator of this site? Confirm its status | Peoria | United States | Recruiting |
| University of California - Davis Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
| Huntsman Cancer Institute Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
| NEXT Oncology Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| University of California San Diego Moores Cancer Center Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| University of California San Francisco Helen Diller Family Comprehensive Cancer Center Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| Fred Hutchinson Cancer Center Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Moffitt Cancer Center Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.