NCT06920004RecruitingPhase 3
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
A Phase 3, Randomized, Double-Blinded, Double-Dummy Study Evaluating the Efficacy and Safety of Intravenous Empasiprubart Versus Intravenous Immunoglobulin in Adults With Chronic Inflammatory Demyelinating Polyneuropathy
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
The main purpose of this study is to compare empasiprubart and IVIg for treating people with CIDP. This study consists of a Part A where participants will either receive empasiprubart and a placebo resembling IVIg, or IVIg and a placebo resembling empasiprubart for 24 weeks (6 months). Following Part A, participants will enter Part B in which all participants will receive empasiprubart for 96 weeks (24 months). More information can be found here: https://clinicaltrials.argenx.com/emvigorate
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 218 (estimated)
- First submitted
- 26 Mar 2025
- Start date
- 22 Aug 2025
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- argenx
- NCT number
- NCT06920004
- EU CT number
- 2024-520097-36-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 218
- From 22 Aug 2025 to the primary completion date, 30 Sept 2027
- 113 sites in 33 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Besides the indication under study, known autoimmune disease or any medical condition that would interfere with an accurate assessment of clinical symptoms of CIDP or puts the participant at undue risk, including polyneuropathy of other causes
Other
- Meets the criteria for possible or sensory CIDP based on EAN/PNS Task Force CIDP guidelines, second revision (2021)
- Use of other long-acting immunomodulatory treatment
Who the study is looking for
- Meets criteria for CIDP based on EAN/PNS Task Force CIDP guidelines, second revision (2021)
- Has either typical CIDP or 1 of the following CIDP variants: motor CIDP, multifocal CIDP (also known as Lewis-Sumner syndrome), focal CIDP, or distal CIDP
- Has responded to IVIg in the past 5 years
- Receiving treatment with IVIg within a standard optimal maintenance dosing regimen, with a minimum weekly IVIg dose of at least 0.125 g/kg
- Has residual disability and active disease
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (113)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Instituto Privado Kremer Coordinator of this site? Confirm its status | Córdoba | Argentina | Recruiting |
| INECO Neurociencias Oroño Coordinator of this site? Confirm its status | Rosario | Argentina | Recruiting |
| Kepler Universitaetsklinikum GmbH Coordinator of this site? Confirm its status | Linz | Austria | Recruiting |
| Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Recruiting |
| Liverpool Hospital Coordinator of this site? Confirm its status | Liverpool | Australia | Recruiting |
| University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD Coordinator of this site? Confirm its status | Pleven | Bulgaria | Completed |
| Alexandrovska University Hospital Coordinator of this site? Confirm its status | Sofia | Bulgaria | Completed |
| Diagnostics And Consultation Center Convex Ltd. Coordinator of this site? Confirm its status | Sofiya | Bulgaria | Completed |
| Escola Bahiana de Medicina e Saude Publica Coordinator of this site? Confirm its status | Salvador | Brazil | Recruiting |
| PSEG Centro de Pesquisa Clinica Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| PSEG Centro de Pesquisa Clinica - Rua Borges Lagoa 1060 Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| University Of Calgary Coordinator of this site? Confirm its status | Calgary | Canada | Recruiting |
| University of Alberta Coordinator of this site? Confirm its status | Edmonton | Canada | Recruiting |
| Black Tusk Research Group Coordinator of this site? Confirm its status | Vancouver | Canada | Recruiting |
| Hôpitaux Universitaires de Genève (HUG) Coordinator of this site? Confirm its status | Geneva | Switzerland | Recruiting |
| Hospital Universitario San Ignacio Coordinator of this site? Confirm its status | Bogotá | Colombia | Recruiting |
| Hospital Alma Mater de Antioquia Coordinator of this site? Confirm its status | Medellín | Colombia | Recruiting |
| Hospital Neurologico de Colombia Fundacion Ivan Jimenez - El Neurologico Coordinator of this site? Confirm its status | Medellín | Colombia | Recruiting |
| Fakultni nemocnice Brno Coordinator of this site? Confirm its status | Brno | Czechia | Recruiting |
| Charite Universitaetsmedizin Berlin KöR Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Medical Center- University of Freiburg Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Kiel | Germany | Recruiting |
| Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen Oe | Denmark | Recruiting |
| Clinic4U OÜ Coordinator of this site? Confirm its status | Tallinn | Estonia | Recruiting |
| Tartu University Hospital Coordinator of this site? Confirm its status | Tartu Linn | Estonia | Recruiting |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital General Universitario Gregorio Marañón Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Hospital Universitario Virgen De La Macarena Coordinator of this site? Confirm its status | Sevilla | Spain | Recruiting |
| Centre hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Recruiting |
| Bicetre Hospital Coordinator of this site? Confirm its status | Le Kremlin Bicetre Cedex | France | Recruiting |
| Centre Hospitalier Regional De Marseille Coordinator of this site? Confirm its status | Marseille | France | Recruiting |
| Centre Hospitalier Universitaire de Nice Coordinator of this site? Confirm its status | Nice | France | Recruiting |
| Assistance Publique Hopitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| Les Hopitaux Universitaires De Strasbourg Coordinator of this site? Confirm its status | Strasbourg Cedex 2 | France | Recruiting |
| Centre Hospitalier Universitaire de Toulouse Coordinator of this site? Confirm its status | Toulouse | France | Recruiting |
| Leeds General Infirmary Coordinator of this site? Confirm its status | Leeds | United Kingdom | Recruiting |
| The National Hospital for Neurology and Neurosurgery - PPDS Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Salford Royal Hospital - PPDS Coordinator of this site? Confirm its status | Salford | United Kingdom | Recruiting |
| University General Hospital of Alexandroupoli Coordinator of this site? Confirm its status | Alexandroupoli | Greece | Recruiting |
| University General Hospital Attikon General Hospital Of West Attica H Agia Varvara Coordinator of this site? Confirm its status | Athens | Greece | Recruiting |
| Clinexpert Kft. Coordinator of this site? Confirm its status | Budapest III | Hungary | Recruiting |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Recruiting |
| The Barzilai University Medical Center Coordinator of this site? Confirm its status | Ashkelon | Israel | Recruiting |
| Hadassah Medical Center - Ein Kerem Coordinator of this site? Confirm its status | Jerusalem | Israel | Recruiting |
| The Chaim Sheba Medical Center Coordinator of this site? Confirm its status | Tel-Hashomer | Israel | Recruiting |
| Azienda Unita Sanitaria Locale Di Bologna Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
| IRCCS Foundation Istituto Neurologico Carlo Besta Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Fondazione Istituto Neurologico Nazionale Casimiro Mondino Coordinator of this site? Confirm its status | Pavia | Italy | Recruiting |
| Azienda Ospedaliero-Universitaria Sant Andre Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Azienda Ospedaliero-Universitaria Policlinico Umberto I Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Azienda Ospedaliera Policlinico Universitario Tor Vergata Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Humanitas Mirasole S.p.A. Coordinator of this site? Confirm its status | Rozzano | Italy | Recruiting |
| Centro Ricerche Cliniche di Verona s.r.l. Coordinator of this site? Confirm its status | Verona | Italy | Recruiting |
| Aomori Prefectural Central Hospital Coordinator of this site? Confirm its status | Aomori | Japan | Recruiting |
| Juntendo University Hospital Coordinator of this site? Confirm its status | Bunkyō City | Japan | Recruiting |
| Chiba University Hospital Coordinator of this site? Confirm its status | Chūōku | Japan | Recruiting |
| Seirei Hamamatsu Hospital Coordinator of this site? Confirm its status | Hiroshima | Japan | Recruiting |
| Juntendo Shizuoka University Hospital Coordinator of this site? Confirm its status | Izunokuni | Japan | Recruiting |
| Osaka Metropolitan University Hospital Coordinator of this site? Confirm its status | Osaka | Japan | Recruiting |
| Saga University Hospital Coordinator of this site? Confirm its status | Saga | Japan | Recruiting |
| Jichi Medical University Hospital Coordinator of this site? Confirm its status | Shimotsuke | Japan | Recruiting |
| General Hospital Tsuchiura Kyodo Hospital Coordinator of this site? Confirm its status | Tsuchiura | Japan | Recruiting |
| Yamaguchi University Hospital Coordinator of this site? Confirm its status | Ube | Japan | Recruiting |
| Inje University Haeundae Paik Hospital Coordinator of this site? Confirm its status | Busan | South Korea | Recruiting |
| Severance Hospital, Yonsei University Health System Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Konkuk University Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Amsterdam UMC Stichting Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Universitair Medisch Centrum Utrecht Coordinator of this site? Confirm its status | Utrecht | Netherlands | Recruiting |
| Oslo University Hospital HF Coordinator of this site? Confirm its status | Oslo | Norway | Recruiting |
| Medicover Integrated Clinical Services Sp. z o.o. Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Recruiting |
| Neurocentrum Bydgoszcz sp. z o.o Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie Coordinator of this site? Confirm its status | Cracow | Poland | Recruiting |
| Linden Sp. z o.o. sp.k. Coordinator of this site? Confirm its status | Cracow | Poland | Recruiting |
| Neurologia Śląska Centrum Medyczne Coordinator of this site? Confirm its status | Katowice | Poland | Recruiting |
| Galen Clinic Coordinator of this site? Confirm its status | Lublin | Poland | Recruiting |
| Clinical Research Center Sp z o o Medic R Sp k Coordinator of this site? Confirm its status | Poznan | Poland | Recruiting |
| Centrum Medyczne Medyk Sp. z o.o. S.K. Coordinator of this site? Confirm its status | Rzeszow | Poland | Recruiting |
| Uniwersytecki Szpital Kliniczny Nr 1 Im. Prof. Tadeusza Sokolowskiego Pum W Szczecinie Coordinator of this site? Confirm its status | Szczecin | Poland | Recruiting |
| Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| Galen Clinic Coordinator of this site? Confirm its status | Warszawa | Poland | Recruiting |
| Unidade Local De Saude De Santo Antonio E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Recruiting |
| Institutul National de Neurologie si Boli Neurovasculare Bucuresti Coordinator of this site? Confirm its status | Bucharest | Romania | Recruiting |
| Brainaxy Clinic S.R.L. Coordinator of this site? Confirm its status | Constanta | Romania | Recruiting |
| Spitalul Clinic Judetean de Urgenta Targu Mures Coordinator of this site? Confirm its status | Târgu Mureş | Romania | Recruiting |
| University Clinical Center of Serbia - Dr Subotica 6 Coordinator of this site? Confirm its status | Belgrade | Serbia | Recruiting |
| University Clinical Center NIS Coordinator of this site? Confirm its status | Niš | Serbia | Recruiting |
| Sahlgrenska University Hospital-Vaestra Goetalandsregionen Coordinator of this site? Confirm its status | Goteborg | Sweden | Recruiting |
| National Neuroscience Institute Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| University Medical Center Ljubljana Coordinator of this site? Confirm its status | Ljubljana | Slovenia | Recruiting |
| Univerzitetni klinični center Maribor Coordinator of this site? Confirm its status | Maribor | Slovenia | Recruiting |
| Univerzitna nemocnica Martin Coordinator of this site? Confirm its status | Martin | Slovakia | Recruiting |
| University of Michigan Hospital Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| University of Alabama Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
| University of Cincinnati Health Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| Colorado Springs Neurological Associates Coordinator of this site? Confirm its status | Colorado Springs | United States | Recruiting |
| Erlanger Health System Coordinator of this site? Confirm its status | Columbia | United States | Recruiting |
| Homestead Associates in Research Inc Coordinator of this site? Confirm its status | Homestead | United States | Recruiting |
| NeuroCarePlus Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| National Neuromuscular Research Institute Coordinator of this site? Confirm its status | Irving | United States | Recruiting |
| University Neurology Coordinator of this site? Confirm its status | Knoxville | United States | Recruiting |
| Visionary Investigators Network Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Baptist Health Medical Group Neurology Coordinator of this site? Confirm its status | Nicholasville | United States | Recruiting |
| Jefferson Health Honickman Center Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Perelman Center for Advanced Medicine Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Samir Macwan, M.D., Inc. Coordinator of this site? Confirm its status | Rancho Mirage | United States | Recruiting |
| Paradigm Health System Coordinator of this site? Confirm its status | Slidell | United States | Recruiting |
| University of South Florida Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| Banner University of Arizona Medical Center Coordinator of this site? Confirm its status | Tucson | United States | Recruiting |
| MedStar Washington Hospital Center Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
| Istanbul Tip Fakultesi Hastanesi (Istanbul Universitesi) Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
| Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi Coordinator of this site? Confirm its status | Samsun | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.