NCT06920238CompletedPhase 1
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
A Phase I Single-Arm Trial to Test the Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use Disorder (CUD)
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression. The main question it aims to answer is: What is the usability, feasibility, and acceptability of Therabot-CALM in persons with Cannabis Use Disorder and Anxiety and/or Depression? Participants will * Take a screening questionnaire * Participate in two virtual 1-hour interviews to provide feedback on app design and suggest features. * Engage with Therabot-CALM in a 4-week clinical trial and provide feedback on their app experience in a third virtual interview
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 15 (actual)
- First submitted
- 10 Mar 2025
- Start date
- 13 Apr 2025
- Primary completion date
- 28 Apr 2026
- Lead sponsor
- Trustees of Dartmouth College
- Diseases
- Depression
- NCT number
- NCT06920238
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 15
- From 13 Apr 2025 to the primary completion date, 28 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Moderate to High risk of STBs as determined by the C-SSRS or baseline questionnaires.
- Current psychosis (as determined by brief psychosis screen).
- Current participation in another digital mental health intervention.
Who the study is looking for
- Is 18 years or older.
- Meet criteria for current CUD (CUDIT-R\>=12) and MDD (PHQ-9\>=10), and/or GAD (GAD-7\>=10).
- Have reliable access to the internet and a compatible device for Therabot-CALM.
- Have willingness and capacity to provide informed consent and commit to participating in all assessments and interventions during the study.
- Attend the first interview.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| 46 Centerra Parkway, Suite 300, Office #333S Coordinator of this site? Confirm its status | Lebanon | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.