NCT06923267Recruiting
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
Ultrasound Evaluation of Cardiac Function During Three Spontaneous Breathing Trials in Intensive Care Unit : A Prospective Interventional Study
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure. The main objective is to find out which spontaneous breathing trial is the least demanding in terms of heart work. Investigators will compare 3 consecutive spontaneous breathing trials in a random order to see if one is superior to the others. Participants will not have to perform any specific procedure apart from breathing without respiratory support during the spontaneous breathing trial. During these trials, the investigator will perform cardiac ultrasound measurements.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 10 Mar 2025
- Start date
- 30 Apr 2025
- Primary completion date
- 9 Apr 2027
- Lead sponsor
- Centre Hospitalier Régional d'Orléans
- NCT number
- NCT06923267
What you commit to
- Study type: Interventional
- Planned participants: 24
- From 30 Apr 2025 to the primary completion date, 9 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Neuromuscular pathology (myasthenia type) preceding hospitalization
- Pregnant or breast-feeding women
- Patient already included in the study
- Protected person (under guardianship or curatorship)
- Person under court protection
- Person not affiliated to a social security scheme
Who the study is looking for
- Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial
- Richmond Agitation Sedation Scale (RASS) between -1 and +1
- Patient at high risk of re-intubation with at least one of the following criteria:
- Underlying cardiac disease (left ventricular dysfunction with left ventricular ejection fraction ≤ 45%, documented ischemic heart disease, chronic atrial fibrillation, known history of cardiogenic pulmonary edema)
- Underlying respiratory disease (COPD, Emphysema, bronchial dilatation, asthma, obesity/hypoventilation syndrome, restrictive lung disease)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Orléans Coordinator of this site? Confirm its status | Orléans | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.