NCT06924996Enrolling by invitation
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct: A Multicenter, Prospective, Cohort Study
Source: ClinicalTrials.gov · Last updated 13 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute basilar artery occlusion with posterior circulation large infarct.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 10 Apr 2025
- Start date
- 1 Jan 2023
- Primary completion date
- 31 Aug 2025
- Lead sponsor
- Feng Gao
- Diseases
- Stroke
- NCT number
- NCT06924996
What you commit to
- Study type: Observational
- Planned participants: 500
- From 1 Jan 2023 to the primary completion date, 31 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Acute cerebral infarction within 48 hours after cardiovascular and cerebrovascular intervention or major surgery (patients more than 48 hours can be enrolled).
Other illness
- Intracranial hemorrhage (except microhemorrhage) on CT/MRI ;
- Known severe allergy to contrast agents (except for mild rash);
- Refractory hypertension (defined as systolic blood pressure \> 185 mmHg or diastolic blood pressure \>110 mmHg) that cannot be controlled by drug therapy;
Other
- CT/MRI revealed large infarction in the cerebellar hemisphere, with significant mass effect causing compression of the fourth ventricle or brainstem;
- CT or MRI showed bilateral complete thalamic infarction;
- Occlusion of anterior and posterior circulation arteries confirmed by CTA/MRA/DSA;
- The presence of intracranial tumors (except for small meningiomas and cerebral aneurysms with a diameter of \<3mm);
- Patients with known or highly suspected chronic basilar artery occlusion.;
- Known pregnant or lactating females, or positive pregnancy test before enrollment;
Who the study is looking for
- Age 18-80 years old;
- Acute ischemic stroke in the posterior circulation, the onset of stroke (or last well known) to the enrollment time within 24 hours;
- CTA/MRA/DSA confirmed acute basilar artery occlusion;
- Posterior circulation large infarct: NCCT or DWI showed pc-ASPECTS ≤ 5 points, or pontine midbrain index (PMI) ≥ 3 points;
- NIHSS score ≥10 points after the onset of the stroke and before enrollment;
- Able to live independently before the onset of the disease (mRS score ≤2 points);
- The subject or legal representative is able to sign the informed consent form.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Tiantan Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.