NCT06929845Recruiting
Organoid Models of Hepatocellular Carcinoma
Organoid Models of Hepatocellular Carcinoma to Test Treatment Efficacy, Exploring Correlations With Tumor Microenvironment and Gut-liver-tumor Axis.
Source: ClinicalTrials.gov · Last updated 21 Sept 2026
Brief summary (registry, in English)
A promising tool to elucidate the molecular characteristics of HCC are patient-derived organoids (PDOs), three-dimensional cultures of cells that self-organise according to tissue-specific patterns and can be used to test the susceptibility of a specific tumour to anticancer agents. In this study, PDOs for HCC will be developed that closely resemble the tumour microenvironment in vivo and mimic the crosstalk of the gut-liver axis to establish a correlation with patient prognosis and test the efficacy of available systemic therapies.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 16 Jul 2024
- Start date
- 1 Oct 2024
- Primary completion date
- 15 Nov 2026
- Lead sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06929845
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 1 Oct 2024 to the primary completion date, 15 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications to HCC resection surgery;
Other illness
- Active viral infection;
Lab values
- Contraindications to liver biopsy (ascites, platelets\<50,000, INR\>1.7);
Age
- Age \< 18 years;
Other
- Refusal to sign informed consent to participate in the study.
Who the study is looking for
- Capacity to express informed consent;
- Age ≥18 years;
- Suspected radiological diagnosis of HCC or diagnosis of HCC with indications for surgical resection.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC CEMAD, Largo A. Gemelli, 8 Coordinator of this site? Confirm its status | Roma | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.