NCT06929897Enrolling by invitation
PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
Comparison of Pulmonary Vein Isolation Alone Versus Pulmonary Vein Isolation With Posterior Wall Isolation for Pulse-Field Ablation in Persistent Atrial Fibrillation: A Prospective Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 16 Jul 2026
Brief summary (registry, in English)
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its clinical application is expanding. \- In patients with persistent atrial fibrillation, can the addition of posterior wall isolation (PWI) following pulmonary vein isolation (PVI) using PFA reduce recurrence? Participants will: * Undergo either PVI alone or PVI with additional left atrial posterior wall isolation (PWI) * Visit the clinic to assess for recurrence of atrial tachyarrhythmias
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 482 (estimated)
- First submitted
- 13 Mar 2025
- Start date
- 3 Jul 2026
- Primary completion date
- 30 Jun 2029
- Lead sponsor
- Ewha Womans University Mokdong Hospital
- Diseases
- Atrial fibrillation
- NCT number
- NCT06929897
What you commit to
- Study type: Interventional
- Planned participants: 482
- From 3 Jul 2026 to the primary completion date, 30 Jun 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of prior cardiac surgery (e.g., Maze procedure, coronary artery bypass grafting)
- Patients with contraindications to anticoagulation therapy and antiarrhythmic drugs
- Valvular atrial fibrillation (e.g., mitral stenosis \> grade 2, mechanical valve, prior mitral valve repair)
- Patients with drug or alcohol addiction
Other illness
- Atrial fibrillation associated with severe congenital heart disease or structural heart disease
- History of atrial fibrillation catheter ablation within the past 12 months
- Patients with active internal bleeding
- Patients with severe comorbid conditions
- Any other conditions deemed by the investigator to make the patient unsuitable for study participation
Lab values
- Patients with severe left ventricular dysfunction (left ventricular ejection fraction \<30%)
Other
- Patients with contraindications to general anesthesia or sedation for the procedure
- Patients with an expected survival of less than one year
- Pregnant or breastfeeding women
Who the study is looking for
- Patients aged 20 to 80 years who are candidates for catheter ablation for persistent atrial fibrillation
- Patients eligible for catheter ablation according to existing clinical guidelines
- Those without clinically significant structural heart disease (e.g., severe mitral regurgitation)
- Those without contraindications to anticoagulation therapy
Age in the registry: 20 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ewha Womans University Mokdong Hospitoal Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.