NCT06933797Completed
Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis
Evaluation of the Changes in LRP5 and TPH1 Levels Due to Periodontal Inflammation
Source: ClinicalTrials.gov · Last updated 18 Apr 2025
Brief summary (registry, in English)
Objectives: The aim of this study was to determine the changes in LRP5 and TPH1 levels in serum and saliva samples due to periodontal inflammation and to evaluate the relationship between these values and clinical periodontal parameters. Methods: Saliva and serum samples were collected from 20 systemically healthy patients with Stage III periodontitis and 20 periodontally healthy control individuals. Salivary and serum LRP5 and TPH1 levels were analyzed using enzyme-linked immunosorbent assay (ELISA). Clinical periodontal parameters, including plaque index (PI), probing pocket depth (PPD), bleeding on probing (BOP), and clinical attachment level (CAL), were recorded.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 40 (actual)
- First submitted
- 8 Apr 2025
- Start date
- 1 Apr 2024
- Primary completion date
- 1 Oct 2024
- Lead sponsor
- Ankara University
- NCT number
- NCT06933797
What you commit to
- Study type: Observational
- Participants enrolled: 40
- From 1 Apr 2024 to the primary completion date, 1 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who have used anti-inflammatory and/or anti-microbial drugs in the last 6 months,
Other illness
- Individuals with psychiatric illness,
- Individuals with any oral infection,
- Individuals with active infectious disease (acute hepatitis, AIDS, tuberculosis), cancer or any systemic condition that may affect periodontal tissues,
Lab values
- Individuals receiving treatment with drugs known to affect periodontal tissues (phenytoin, cyclosporine A, calcium channel blockers)
Other
- Pregnant/lactating individuals,
- Individuals who have undergone periodontal treatment in the last 1 year,
- Individuals with \<16 teeth, excluding molars,
- Individuals with alcohol dependence,
Who the study is looking for
- \>18 years old,
- At least 16 permanent teeth except 3rd molars,
- Individuals who do not use orthodontic appliances,
- Individuals who are not pregnant or lactating,
- Individuals without any systemic disease that may affect periodontal health,
- Systemically healthy individuals,
- Individuals who have not used anti-inflammatory and/or anti-microbial drugs in the last 6 months,
- Individuals who have not received periodontal treatment in the last 1 year
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ankara University, Faculty of Dentistry, Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.