NCT06935305Recruiting
OSNA Versus Ultrastaging to Detect Sentinel Lymph Node Metastasis in Endometrial Cancer
One Step Nucleic Acid Amplification (OSNA) Versus Ultrastaging to Detect Sentinel Lymph Node Metastasis in Endometrial Cancer: a Randomized, Multicenter, Controlled Trial (SENT-OSNA Study)
Source: ClinicalTrials.gov · Last updated 18 Nov 2025
Brief summary (registry, in English)
Patients enrolled in the study will be randomized before surgery: in one study arm, the search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method (standard), while in the other arm it will be conducted using the OSNA method.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1922 (estimated)
- First submitted
- 9 Feb 2025
- Start date
- 30 Jul 2025
- Primary completion date
- 17 Sept 2026
- Lead sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Diseases
- Endometrial cancer, Childhood cancers
- NCT number
- NCT06935305
What you commit to
- Study type: Interventional
- Planned participants: 1922
- From 30 Jul 2025 to the primary completion date, 17 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Fertility sparing surgery
- Neoadjuvant therapy
- Previous surgery to pelvic lymph nodes
Other
- Uterine sarcoma (including endometrial stromal sarcoma)
- Dedifferentiated histology
- Undifferentiated histology
- Lymph nodes with short axis \>15 mm at pre-operative imaging
Who the study is looking for
- Histologically confirmed endometrial cancer
- Apparent (pre-operative) FIGO stage I-II
- Radical surgery
- Attempt of SLN mapping
Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.