NCT06938100Recruiting
Genotype, Clinical Features and Imaging of Neuroradiological Abnormalities in CADASIL
Source: ClinicalTrials.gov · Last updated 31 Aug 2026
Brief summary (registry, in English)
The project aims to retrospectively and prospectively analyze a population of CADASIL patients in order to study the natural history of the disease by correlating the symptom spectrum with genetic risk and specific neuroradiological and biological markers \- Stratifying patients according to their disease risk, this could contribute to the discovery of personalized therapeutic targets.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 3 Apr 2025
- Start date
- 21 Nov 2023
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- NCT number
- NCT06938100
What you commit to
- Study type: Observational
- Planned participants: 100
- From 21 Nov 2023 to the primary completion date, 30 Apr 2027
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- are unable to give consent for the study due to aphasic or cognitive impairment or because they are deceased at the time of enrollment and their next of kin refuse to give consent for study participation.
Other
- do not meet the diagnostic criteria of CADASIL;
Who the study is looking for
- patients of either sex older than 18 years of age;
- finding of a pathogenic mutation on genetic analysis of NOTCH3;
- in the absence of unambiguous mutation, presence of characteristic deposits (GOM) within small vessels at skin biopsy
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario de la Princesa, Madrid Coordinator of this site? Confirm its status | Madrid | Spain | Not yet recruiting |
| Fondazione IRCCS Istituto Neurologico Carlo Besta Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.