NCT06940609RecruitingPhase 2
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)
Source: ClinicalTrials.gov · Last updated 15 Jul 2026
Brief summary (registry, in English)
The goal of this clinical trial is to test whether a type of rapid outpatient brain stimulation that uses magnetic fields, called accelerated intermittent theta burst stimulation (iTBS), can treat symptoms such as brain fog, depression, and anxiety in patients with Long COVID. The main questions it aims to answer are: * Is iTBS effective and feasible for reducing Long COVID symptoms? We will measure these symptoms using the Symptom Burden Questionnaire. * Are there changes in inflammatory brain chemicals associated with treatment with iTBS? We will be looking at levels of choline in the brain, which is thought to be related to inflammation. Researchers will compare sham versus active forms of iTBS to see if the active group has greater improvement in symptoms. Participants will complete symptom surveys, cognitive tests, and magnetic resonance imaging scans at the beginning, middle, and end of treatment.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 2 Apr 2025
- Start date
- 7 Jul 2025
- Primary completion date
- 30 Jun 2029
- Lead sponsor
- University of New Mexico
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT06940609
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 60
- From 7 Jul 2025 to the primary completion date, 30 Jun 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- a prior history of other neurological disease, or any history of seizures, so as to reduce risk of exacerbation of epilepsy or other neurological symptoms;
Other illness
- history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation
- history of ongoing substance/alcohol dependence, to reduce confounding effects on diagnosis and brain imaging
- any condition that would prevent the subject from completing the protocol
Other
- presence of any implanted electrical device (e.g., pacemaker), to reduce risk of device malfunction from rTMS
- recent medical hospitalization (within four weeks), to reduce risk of medical decompensation during the study
- appointment of a legal representative, to avoid coercion of a vulnerable population
- any ongoing litigation related to medical diagnosis, or disability, to prevent interference with legal proceedings
- any contraindication to MRI
- membership in an identified vulnerable population, including minors, pregnant women, and prisoners, so as to prevent coercion.
Who the study is looking for
- aged 18-80
- a documented diagnosis of PASC with evidence of ongoing symptoms as demonstrated by score of 12 on the NIH RECOVER Symptom List
- have "brain fog" or cognitive difficulties as one of the ongoing symptoms
- are fluent in English
- if taking psychotropic medications, have been on stable doses for the past month.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of New Mexico Health Science Center Coordinator of this site? Confirm its status | Albuquerque | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.