NCT06941844Active, not recruitingPhase 3
A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)
A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled, 12-Week Study (Part A) With a 40-Week Open-label Extension (Part B) Evaluating the Efficacy and Safety of Oral DT120 Compared to Placebo in the Treatment of Adults With Major Depressive Disorder - Emerge
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Emerge
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 149 (actual)
- First submitted
- 16 Apr 2025
- Start date
- 14 Apr 2025
- Primary completion date
- 20 May 2026
- Lead sponsor
- Definium Therapeutics US, Inc.
- Diseases
- Depression
- NCT number
- NCT06941844
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 149
- From 14 Apr 2025 to the primary completion date, 20 May 2026
- 22 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Certain psychiatric disorders (other than major depressive disorder)
- First degree relative with or lifetime history of a psychotic disorder or bipolar disorder
- Current diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine
- Any clinically significant unstable illness
Who the study is looking for
- Diagnosis of MDD per DSM-5
- Male or female aged 18 to 74
- Currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration
- MADRS Total Score ≥26
- CGI-S Score ≥4
Age in the registry: 18 years to 74 years · Sex: All · Does not accept healthy volunteers
Sites (22)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Austin Clinical Trial Partners Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Sheppard Pratt Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Memory Clinic, Inc. Coordinator of this site? Confirm its status | Bennington | United States | Unknown status |
| Cenexel HRI Coordinator of this site? Confirm its status | Berlin | United States | Unknown status |
| Adams Clinical Boston Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Neuro-Behavioral Clinical Research Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Uptown Research Institute (URI), LLC Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Cincinnati Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| University of Missouri Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
| Mountain View Clinical Research, Inc Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| CNS, LLC (Jacksonville) Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Kadima Neuropsychiatry Institute Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Preferred Research Partners, Inc Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| CNS, LLC (Memphis) Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Cedar Clinical Research Coordinator of this site? Confirm its status | Murray | United States | Unknown status |
| Columbia - New York State Psychiatric Institute Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Adams Clinical Harlem Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Charter Research Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| CNS, LLC (Orlando) Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Adams Clinical Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Psychedelic Science Institute Coordinator of this site? Confirm its status | Santa Monica | United States | Unknown status |
| Adams Clinical Coordinator of this site? Confirm its status | Watertown | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.