NCT06947135Recruiting
Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury
The Effect of Targeted Stellate Ganglion Morphine Infiltration on Reperfusion Injury in STEMI Patients After Primary PCI: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 17 Dec 2025
Brief summary (registry, in English)
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion injury in AMI patients. It will also assess the safety of injecting morphine around the stellate ganglion via ultrasound guidance. The main questions it aims to answer are: 1. Does morphine regulate stellate ganglion function to reduce myocardial ischemia/reperfusion injury in AMI patients? 2. What medical problems do participants experience when receiving injected morphine around the stellate ganglion? Researchers will compare morphine to a placebo saline (as a control group) to determine whether stellate ganglion infiltration with morphine effectively treats patients with AMI following primary PCI. Participants will: * Receive a single injection of morphine or saline around the stellate ganglion. * Evaluate the percentage of infarct size 7 days after surgery, or at discharge if the duration is shorter than 7 days. * Record their symptoms and any major adverse cardiovascular and cerebrovascular events within 30 days post-surgery.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 166 (estimated)
- First submitted
- 12 Apr 2025
- Start date
- 29 May 2025
- Primary completion date
- 4 Jun 2026
- Lead sponsor
- The Second Hospital of Anhui Medical University
- Diseases
- Coronary artery disease
- NCT number
- NCT06947135
What you commit to
- Study type: Interventional
- Planned participants: 166
- From 29 May 2025 to the primary completion date, 4 Jun 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with coagulation disorders due to systemic diseases and those who are currently using anticoagulants and are not suitable for injection;
Other illness
- Patients with severe complications of myocardial infarction, such as uncontrollable acute left heart failure and pulmonary edema, severe cardiogenic shock after cardiopulmonary resuscitation, severe mechanical complications including ventricular septal defect, papillary muscle rupture, and rupture of the left ventricular free wall;
- Patients with old myocardial infarction, or cardiomyopathy, or malignant arrhythmias controlled by antiarrhythmic drugs;
- Patients allergic to opioids or with a history of opioid addiction and those participating in other clinical studies;
- Patients with severe organ dysfunction or failure, such as liver failure, renal failure, and respiratory failure;
- Patients with severe infections;
- Patients with severe mental illness that cannot cooperate and those taking antipsychotic drugs;
Other
- Pregnant or breastfeeding women;
- Other patients considered unsuitable for this study by the researchers.
Who the study is looking for
- Aged ≥18 years, Male or Female.
- Acute ST-segment elevation myocardial infarction (STEMI) patients planned for percutaneous coronary intervention (PCI). Acute STEMI is defined as: electrocardiogram shows ST-segment elevation ≥0.2 mV in two or more adjacent leads, or new left bundle branch block (LBBW).
- Within 24 hours of the onset of infarct-related chest pain.
- Obtaining informed consent from the patient and their family.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Second Xiangya Hospital of Central South University Coordinator of this site? Confirm its status | Changsha | China | Recruiting |
| The First Affiliated Hospital of Anhui Medical University Coordinator of this site? Confirm its status | Hefei | China | Recruiting |
| The Second Affiliated Hospital Of Anhui Medical University Coordinator of this site? Confirm its status | Hefei | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.