The Mechanism of Endogenous Nociceptin/Orphanin FQ(N/OFQ) and β1-adrenoceptor Autoantibody in Promoting Ischemic Arrhythmia in Rats

Brief summary (registry, in English)

In the early stage of ischemic arrhythmia, endogenous N/OFQ regulates the expression of β 1-AA, mediates the internalization of β 1-AR by PKC/ERK1/2, and thus affects the occurrence of arrhythmia. Further clarify the regulatory mechanism of N/OFQ on β 1-AR internalization and arrhythmia, providing experimental basis for drug development and target exploration of clinical ischemic arrhythmia; To observe the relationship between endogenous N/OFQ and β 1-AA in serum of patients with coronary heart disease and diabetes.

What you commit to

• Study type: Observational
• Planned participants: 60
• From 1 May 2025 to the primary completion date, 1 May 2026
• No sites listed in no country
• Visits and tests: ask the trial team, the registry does not list them

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Who cannot take part

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Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers

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