NCT06948422Active, not recruitingPhase 3
A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants With Hypertension and Obesity or Overweight: Randomized, Double-Blind, Placebo-Controlled Trials (ATTAIN-HYPERTENSION)
Source: ClinicalTrials.gov · Last updated 29 May 2026
Brief summary (registry, in English)
The GZPL master protocol will support 2 independent studies, J2A-MC-GZL1 (GZL1) and J2A-MC-GZL2 (GZL2). The purpose of this study is to create a framework to evaluate the safety and efficacy of orforglipron for the treatment of hypertension in participants with obesity or overweight.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 974 (estimated)
- First submitted
- 21 Apr 2025
- Start date
- 30 Apr 2025
- Primary completion date
- Sept 2027
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity, High blood pressure
- NCT number
- NCT06948422
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 974
- From 30 Apr 2025 to the primary completion date, Sept 2027
- 99 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have had any of the following conditions within 90 days prior to screening.
- hospitalization for hypertension or for congestive heart failure
- acute coronary syndrome or acute myocardial infarction, or
- cerebrovascular accident (stroke).
Other illness
- Has known secondary causes of hypertension
- Have type 1 diabetes (T1D)
- Have acute or chronic hepatitis, including a history of autoimmune hepatitis
Lab values
- Have heart failure with reduced ejection fraction (HFrEF) diagnosis
Other
- Has SBP ≥170 mmHg and/or DBP ≥110 mmHg at Visit 1 or at Visit 3.
Who the study is looking for
- Has systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at screening (Visit 1).
- Has SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at week 0 (Visit 3).
- Untreated for hypertension, or on stable antihypertensive medications ≥ 30 days prior to Visit 1.
- Have a body mass index (BMI) ≥ 25 kg/m².
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (99)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CEMEDIC Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Instituto Médico Especializado (IME) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| CIPREC Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Instituto de Investigaciones Clínicas Córdoba Coordinator of this site? Confirm its status | Córdoba | Argentina | Unknown status |
| Centro de Investigaciones Clínicas Baigorria Coordinator of this site? Confirm its status | Granadero Baigorria | Argentina | Unknown status |
| Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| INECO Neurociencias Oroño Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Santa Maria de la Salud Centro Medico Coordinator of this site? Confirm its status | San Isidro | Argentina | Unknown status |
| Beijing Pinggu District Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| China-Japan Union Hospital Coordinator of this site? Confirm its status | Changchun | China | Unknown status |
| Changde First People's Hospital Coordinator of this site? Confirm its status | Changde | China | Unknown status |
| Sichuan Provincial People's Hospital Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| The Second Affiliated Hospital of Chongqing Medical University - Yuzhong Campus Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
| Jinan Central Hospital Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Lishui Central Hospital Coordinator of this site? Confirm its status | Lishui | China | Unknown status |
| The First Affiliated Hospital of Henan University of Science &Technology Coordinator of this site? Confirm its status | Luoyang Shi | China | Unknown status |
| Ruijin Hospital Shanghai Jiaotong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Siping Central People's Hospital Coordinator of this site? Confirm its status | Siping | China | Unknown status |
| Wuxi People's Hospital Coordinator of this site? Confirm its status | Wuxi | China | Unknown status |
| Shaanxi provincial people's hospital Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| Top Moravia Health Coordinator of this site? Confirm its status | Brno | Czechia | Unknown status |
| Ordinace Rihackovi, s.r.o. Coordinator of this site? Confirm its status | Brno | Czechia | Unknown status |
| CTC Hodonin s.r.o. Coordinator of this site? Confirm its status | Hodonín | Czechia | Unknown status |
| MUDr. Sarka Drinkova Coordinator of this site? Confirm its status | Ledeč nad Sázavou | Czechia | Unknown status |
| CCR Ostrava s.r.o Coordinator of this site? Confirm its status | Ostrava | Czechia | Unknown status |
| Diahelp s.r.o Coordinator of this site? Confirm its status | Pardubice V | Czechia | Unknown status |
| Praglandia s.r.o. Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Angiocentrum Komorany Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Clinoxus Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Zentrum für Klinische Studien Bad Homburg Coordinator of this site? Confirm its status | Bad Homburg | Germany | Unknown status |
| FutureMeds GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Zentrum fur klinische Forschung - Köln Coordinator of this site? Confirm its status | Cologne | Germany | Unknown status |
| Universitaetsklinikum Carl Gustav Carus Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Unknown status |
| Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien Coordinator of this site? Confirm its status | Dresden | Germany | Unknown status |
| Medizentrum Essen Borbeck Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| AmBeNet GmbH Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
| Familienmedizinisches Zentrum Radowsky Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
| RED-Institut GmbH Coordinator of this site? Confirm its status | Oldenburg | Germany | Unknown status |
| CHUAC-Complejo Hospitalario Universitario A Coruña Coordinator of this site? Confirm its status | A Coruña | Spain | Unknown status |
| Hospital San Rafael - La Coruña Coordinator of this site? Confirm its status | A Coruña | Spain | Unknown status |
| EAP Sardenya Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| EAP Osona Sud - Alt Congost S.L.P Coordinator of this site? Confirm its status | Centelles | Spain | Unknown status |
| Complejo Asistencial Universitario de León - Hospital de León Coordinator of this site? Confirm its status | León | Spain | Unknown status |
| Hospital Quiron Infanta Luisa Coordinator of this site? Confirm its status | Seville | Spain | Unknown status |
| Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE) Coordinator of this site? Confirm its status | Seville | Spain | Unknown status |
| Athens Medical Center - Psychikon branch Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| General Hospital of Athens "G. Gennimatas" Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| University Hospital of Ioannina Coordinator of this site? Confirm its status | Ioannina | Greece | Unknown status |
| Papageorgiou General Hospital of Thessaloniki Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| G. Gennimatas General Hospital of Thessaloniki Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| AHEPA University General Hospital of Thessaloniki Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Life Care Hospital and Research Centre Coordinator of this site? Confirm its status | Bangalore | India | Unknown status |
| All India Institute of Medical Sciences Coordinator of this site? Confirm its status | Bhubaneswar | India | Unknown status |
| G.B. Pant Institute of Postgraduate Medical Education & Research Coordinator of this site? Confirm its status | New Delhi | India | Unknown status |
| Ashirwad Hospital and Research Centre Coordinator of this site? Confirm its status | Ulhasnagar | India | Unknown status |
| Tokyo-Eki Center-building Clinic Coordinator of this site? Confirm its status | Chūōku | Japan | Unknown status |
| Fukuwa Clinic Coordinator of this site? Confirm its status | Chūōku | Japan | Unknown status |
| Takai Internal Medicine Clinic Coordinator of this site? Confirm its status | Kamakura-shi | Japan | Unknown status |
| Mikannohana Clinic, Diabetes, Endocrinology and Metabolism Coordinator of this site? Confirm its status | Matsuyama | Japan | Unknown status |
| Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic Coordinator of this site? Confirm its status | Yamato-shi | Japan | Unknown status |
| Uniwersytecki Szpital Kliniczny w Białymstoku Coordinator of this site? Confirm its status | Bialystok | Poland | Unknown status |
| Centrum Medyczne "Hipokrates" s.c. Elżbieta i Grzegorz Grześk Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Unknown status |
| NZOZ Centrum Medyczne KERmed Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Unknown status |
| IRMED Coordinator of this site? Confirm its status | Piotrkow Trybunalski | Poland | Unknown status |
| Wojewodzki Szpital im Sw Ojca Pio w Przemyslu Coordinator of this site? Confirm its status | Przemyśl | Poland | Unknown status |
| Private Practice - Dr. Robert Witek Coordinator of this site? Confirm its status | Tarnów | Poland | Unknown status |
| Balsam Medica Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
| NZOZ Regionalna Poradnia Diabetologiczna Coordinator of this site? Confirm its status | Wroclaw | Poland | Unknown status |
| Dorado Medical Complex Coordinator of this site? Confirm its status | Dorado | Puerto Rico | Unknown status |
| Puerto Rico Medical Research Coordinator of this site? Confirm its status | Ponce | Puerto Rico | Unknown status |
| Sinai Hospital of Baltimore Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Ascension Saint Agnes Heart Care Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Excel Medical Clinical Trials Coordinator of this site? Confirm its status | Boca Raton | United States | Unknown status |
| Care Access - Brandon Coordinator of this site? Confirm its status | Brandon | United States | Unknown status |
| StudyMetrix Research Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| Remington Davis, Inc. Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Valley Clinical Trials, Inc. Coordinator of this site? Confirm its status | Covina | United States | Unknown status |
| Primed Clinical Research Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Dallas Heart and Vascular Consultants, PA Coordinator of this site? Confirm its status | Duncanville | United States | Unknown status |
| East-West Medical Research Institute Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Northeast Research Institute - Downtown Office Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Palm Research Center Sunset Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Excel Clinical Research, LLC Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Carient Heart & Vascular - Manassas Coordinator of this site? Confirm its status | Manassas | United States | Unknown status |
| Care Access - Mauldin Coordinator of this site? Confirm its status | Mauldin | United States | Unknown status |
| Texas Institute of Cardiology PA Coordinator of this site? Confirm its status | McKinney | United States | Unknown status |
| Lucida Clinical Trials Coordinator of this site? Confirm its status | New Bedford | United States | Unknown status |
| Health Research of Hampton Roads, Inc. Coordinator of this site? Confirm its status | Newport News | United States | Unknown status |
| North Hills Family Medicine/North Hills Medical Research Coordinator of this site? Confirm its status | North Richland Hills | United States | Unknown status |
| Valley Clinical Trials, Inc. Coordinator of this site? Confirm its status | Northridge | United States | Unknown status |
| Advanced Research Institute Coordinator of this site? Confirm its status | Ogden | United States | Unknown status |
| Elite Clinical Studies, LLC Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Eastside Research Associates Coordinator of this site? Confirm its status | Redmond | United States | Unknown status |
| National Clinical Research, Inc Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Rochester Clinical Research, LLC Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Care Access - St. Petersburg Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Advanced Research Institute - Tigard Coordinator of this site? Confirm its status | Tigard | United States | Unknown status |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Chase Medical Research, LLC Coordinator of this site? Confirm its status | Waterbury | United States | Unknown status |
Related publications
- Study design, rationale, and baseline characteristics of ATTAIN-HYPERTENSION, a phase 3 trial of the oral GLP-1 receptor agonist orforglipron for hypertension.Am J Prev Cardiol · 2026 · PMID 42830762
This page is information, not medical advice. Discuss any trial with your doctor.