NCT06950060Active, not recruiting
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors. The study compares three groups: one performing aerobic cycling at an intensity that elevates lactate levels, one performing low-intensity exercise, and one receiving health education without exercise. All participants will complete motor learning tasks and undergo brain-stimulation testing using transcranial magnetic stimulation (TMS) to assess how well the brain responds to training. The goal is to understand whether different types of exercise can improve brain function, movement, and memory, and how the body's response to exercise (like lactate levels) might support brain health. This research may help identify low-cost, non-invasive interventions-such as targeted exercise-that improve motor and cognitive outcomes in aging and stroke recovery.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 3 Apr 2025
- Start date
- 15 Jul 2026
- Primary completion date
- 1 Sept 2029
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Stroke
- NCT number
- NCT06950060
What you commit to
- Study type: Interventional
- Planned participants: 48
- From 15 Jul 2026 to the primary completion date, 1 Sept 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of epilepsy or seizures
- Current substance abuse or uncontrolled psychiatric disorder
- Severe cardiovascular disease or unstable medical condition
- Contraindications to TMS or exercise testing (e.g., implanted neurostimulators, severe hypertension)
Other
- Pregnancy
- Participation in another interventional trial within the past 30 days
Who the study is looking for
- For All Participants:
- Able to provide informed consent
- Right-handed (for TMS consistency)
- English-speaking
- Clearance for moderate-intensity aerobic exercise
- Able to safely sit and pedal a stationary cycle ergometer
- No contraindications to TMS (e.g., no metal in skull, pacemakers, or seizure history)
- Younger Adults (18-35):
- No history of neurological or psychiatric conditions
- Not currently on medications that affect the central nervous system
- Older Adults (60-85):
- No diagnosis of dementia
- Independent in activities of daily living
- No stroke history
- Stroke Survivors (40-85):
- At least 6 months post-stroke (chronic phase)
- Medically stable and cleared for aerobic exercise
- Able to engage in motor learning task (with or without hemiparetic adaptations)
Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CH19 933 19th St S Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.