NCT06951906RecruitingPhase 4
Imaging Biomarkers of FOG Response to DBS
Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS). The objective of this study is to better understand the FOG response to DBS. Prior to DBS, participants will undergo an MRI scan, behavioral assessment related to walking, a cognitive evaluation, and assessment of other Parkinson's disease symptoms. Following DBS, participants will repeat these assessments at multiple timepoints over the period of one year. Overall, participants will complete a total of 7 visits over a period of approximately 1 year.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 54 (estimated)
- First submitted
- 23 Apr 2025
- Start date
- 11 Nov 2024
- Primary completion date
- Nov 2029
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Parkinson disease
- NCT number
- NCT06951906
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 54
- From 11 Nov 2024 to the primary completion date, Nov 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- contraindications to MRI, including inability to lie supine in the scanner environment, pregnancy, and non-MRI compatible metal implants.
Other illness
- a history of other significant gait impairment unrelated to PD (e.g. orthopedic deformities).
Other
- inability to complete gait assessments (timed-up-and-go task) in the OFF state without assistance or assist devices.
- implantation of non-3 T MRI-compatible DBS devices.
Who the study is looking for
- \>40 years of age.
- diagnosis of PD based on UK Brain Bank diagnostic criteria.
- presence of FOG, defined as a score of 1 on part 1 of the nFOGQ and confirmed by objective evaluation (a score of 1 represents a positive response of having experienced such an episode over the last month).
- clinically selected at the MUSC DBS Conference to undergo STN-DBS surgery.
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.