NCT06952153Recruiting
Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment
Comparison of Phaco Surgery and Goniosynechialysis Versus Trabeculectomy Outcomes in Glaucoma Patients
Source: ClinicalTrials.gov · Last updated 11 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma. The main questions it aims to answer are: * Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy? * What are the rates of postoperative complications or adverse events between the two surgical approaches? * How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications? Researchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma. Participants will: Be randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 82 (estimated)
- First submitted
- 23 Apr 2025
- Start date
- 1 Jun 2025
- Primary completion date
- 30 Jul 2027
- Lead sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
- Diseases
- Glaucoma
- NCT number
- NCT06952153
What you commit to
- Study type: Interventional
- Planned participants: 82
- From 1 Jun 2025 to the primary completion date, 30 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior ocular surgeries or laser peripheral iridotomy (PI)
- Chronic corticosteroid use
Other illness
- Allergy to 5-fluorouracil (5-FU), if used postoperatively
- Irreversible corneal disease
Other
- Very advanced glaucoma (only light perception vision)
- Secondary angle-closure etiologies
- Poor follow-up compliance
- Cataract grade 4 or 5 (LOCS III)
- Phacomorphic, phacolytic, or subluxated cataracts
Who the study is looking for
- Age ≥ 40 years
- Peripheral anterior synechiae (PAS) \>180°
- Glaucomatous optic neuropathy with visual field loss
- Intraocular pressure (IOP) \> 21 mmHg despite medication
- Ability to consent and comply with follow-up
- Cataract grade 1 to 3 according to LOCS III
- Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20/40 Snellen or worse)
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| HCMC University of Medicine and Pharmacy Coordinator of this site? Confirm its status | Ho Chi Minh City | Vietnam | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.