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NCT06952400Recruiting

The Registry Study of Genetic Alterations of Melanoma in Taiwan

T1622 The Registry Study of Genetic Alterations of Melanoma in Taiwan

Source: ClinicalTrials.gov · Last updated 6 May 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

Cutaneous melanoma is the most aggressive malignancy in skin cancers. Cutaneous melanoma is a rare disease in Taiwan with an incidence rate of around 1/100,000. Acral lentiginous melanoma is the most common subtype and comprises more than half of cutaneous melanoma in Asia including Taiwan but only 1% in Caucasians. In addition, mucosal melanoma accounts for more than 20% of malignancy melanoma in Taiwan but only 1% in Caucasians. Acral and mucosal melanomas have distinct epidemiological, clinical, pathological and genetic features from non-acral melanoma which is commonly seen in Western countries. Comparing with melanoma in Caucasians, Asian melanoma has higher recurrence rate after primary surgery, lower response rate to immunotherapy, and shorter progression-free survival for immunotherapy and targeted therapy leading generally poor survival outcomes regardless stage.

Status (registry)
Recruiting
Study type
Observational
Enrollment
250 (estimated)
First submitted
6 Apr 2025
Start date
22 Aug 2022
Primary completion date
31 Dec 2025
Lead sponsor
National Health Research Institutes, Taiwan
Diseases
Melanoma
NCT number
NCT06952400

What you commit to

  • Study type: Observational
  • Planned participants: 250
  • From 22 Aug 2022 to the primary completion date, 31 Dec 2025
  • 16 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Inability to cooperate by providing a complete medical history
  • No available tumor tissues for genetic testing (archived tissue sampling more than 5 years from screening date)
  • Undesirable compliance (Mental status is not fit for further treatment or data collection.)

Who the study is looking for

  • Age \> 18 years old
  • Pathologically confirmed melanoma. (Patients with additional malignancies requiring treatment or follow-up are allowed. Only treatment for melanoma should be recorded).
  • ECOG performance status \< 3
  • Cohort 1(early acral melanoma): melanoma, stage I/II; Cohort 2 (locally advanced acral melanoma): melanoma, stage III, resectable; and Cohort 3 (advanced): unresectable / metastatic melanoma, stage III/IV or recurrent melanoma (unresectable). Staging is based on AJCC Cancer Staging System 8th edition). The patients with advanced melanoma with available comprehensive NGS report are included in cohort 4.
  • Willingness to provide archival or newly obtained tumor tissues for this study proposal
  • Life expectancy more than 3 months -
  • Patients fully understand the protocol with the willingness to have regular follow-up

Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (16)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Chang-Gung Memorial Hospital - Chiayi
Coordinator of this site? Confirm its status
Chiayi CityTaiwanRecruiting
Kaohsiung Medical University
Coordinator of this site? Confirm its status
Kaohsiung CityTaiwanRecruiting
Kaohsiung Chang Gung Memorial Hospital
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Kaohsiung CityTaiwanRecruiting
National Taiwan University Hospital ,NTUH Hsin-Chu Branch
Coordinator of this site? Confirm its status
Sindian CityTaiwanRecruiting
China Medical University Hospital
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TaichungTaiwanRecruiting
Taichung Veterans General Hospital
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TaichungTaiwanRecruiting
Chung Shan Medical University Hospital
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TaichungTaiwanRecruiting
National Cheng Kung University Hospital
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TainanTaiwanRecruiting
MacKay Memorial Hospital
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TaipeiTaiwanRecruiting
Wan Fang Hospital, Taipei Medical University
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TaipeiTaiwanRecruiting
National Taiwan University Hospital
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TaipeiTaiwanRecruiting
Taipei Veterans General Hospital
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TaipeiTaiwanRecruiting
Taipei Medical University -Ministry of Health and Welfare Shuang-Ho Hospital
Coordinator of this site? Confirm its status
TaipeiTaiwanRecruiting
Koo Foundation Sun Yat-Sen Cancer Center
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TaipeiTaiwanRecruiting
Taoyuan General Hospital, Ministry of Health and Welfare
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TaoyuanTaiwanRecruiting
Chang Gung Memorial Hospital, Linkou
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TaoyuanTaiwanRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.