NCT06952400Recruiting
The Registry Study of Genetic Alterations of Melanoma in Taiwan
T1622 The Registry Study of Genetic Alterations of Melanoma in Taiwan
Source: ClinicalTrials.gov · Last updated 6 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Cutaneous melanoma is the most aggressive malignancy in skin cancers. Cutaneous melanoma is a rare disease in Taiwan with an incidence rate of around 1/100,000. Acral lentiginous melanoma is the most common subtype and comprises more than half of cutaneous melanoma in Asia including Taiwan but only 1% in Caucasians. In addition, mucosal melanoma accounts for more than 20% of malignancy melanoma in Taiwan but only 1% in Caucasians. Acral and mucosal melanomas have distinct epidemiological, clinical, pathological and genetic features from non-acral melanoma which is commonly seen in Western countries. Comparing with melanoma in Caucasians, Asian melanoma has higher recurrence rate after primary surgery, lower response rate to immunotherapy, and shorter progression-free survival for immunotherapy and targeted therapy leading generally poor survival outcomes regardless stage.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 250 (estimated)
- First submitted
- 6 Apr 2025
- Start date
- 22 Aug 2022
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- National Health Research Institutes, Taiwan
- Diseases
- Melanoma
- NCT number
- NCT06952400
What you commit to
- Study type: Observational
- Planned participants: 250
- From 22 Aug 2022 to the primary completion date, 31 Dec 2025
- 16 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Inability to cooperate by providing a complete medical history
- No available tumor tissues for genetic testing (archived tissue sampling more than 5 years from screening date)
- Undesirable compliance (Mental status is not fit for further treatment or data collection.)
Who the study is looking for
- Age \> 18 years old
- Pathologically confirmed melanoma. (Patients with additional malignancies requiring treatment or follow-up are allowed. Only treatment for melanoma should be recorded).
- ECOG performance status \< 3
- Cohort 1(early acral melanoma): melanoma, stage I/II; Cohort 2 (locally advanced acral melanoma): melanoma, stage III, resectable; and Cohort 3 (advanced): unresectable / metastatic melanoma, stage III/IV or recurrent melanoma (unresectable). Staging is based on AJCC Cancer Staging System 8th edition). The patients with advanced melanoma with available comprehensive NGS report are included in cohort 4.
- Willingness to provide archival or newly obtained tumor tissues for this study proposal
- Life expectancy more than 3 months -
- Patients fully understand the protocol with the willingness to have regular follow-up
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (16)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chang-Gung Memorial Hospital - Chiayi Coordinator of this site? Confirm its status | Chiayi City | Taiwan | Recruiting |
| Kaohsiung Medical University Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Recruiting |
| Kaohsiung Chang Gung Memorial Hospital Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Recruiting |
| National Taiwan University Hospital ,NTUH Hsin-Chu Branch Coordinator of this site? Confirm its status | Sindian City | Taiwan | Recruiting |
| China Medical University Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Recruiting |
| Taichung Veterans General Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Recruiting |
| Chung Shan Medical University Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Recruiting |
| National Cheng Kung University Hospital Coordinator of this site? Confirm its status | Tainan | Taiwan | Recruiting |
| MacKay Memorial Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Recruiting |
| Wan Fang Hospital, Taipei Medical University Coordinator of this site? Confirm its status | Taipei | Taiwan | Recruiting |
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Recruiting |
| Taipei Veterans General Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Recruiting |
| Taipei Medical University -Ministry of Health and Welfare Shuang-Ho Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Recruiting |
| Koo Foundation Sun Yat-Sen Cancer Center Coordinator of this site? Confirm its status | Taipei | Taiwan | Recruiting |
| Taoyuan General Hospital, Ministry of Health and Welfare Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Recruiting |
| Chang Gung Memorial Hospital, Linkou Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.