NCT06956781Recruiting
Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
Optimizing Behavioral Health Services Following Pediatric Trauma Exposure
Source: ClinicalTrials.gov · Last updated 8 Apr 2026
Brief summary (registry, in English)
The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD? Researchers will: Compare components to a psychological placebo to estimate their effects and measure how they work Examine how components work alone and in conjunction with other components Participants will: Receive different combinations of components and placebo Attend weekly treatment sessions Provide information to evaluate changes in PTSD
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 24 Apr 2025
- Start date
- 15 Mar 2026
- Primary completion date
- Aug 2028
- Lead sponsor
- University of Rochester
- NCT number
- NCT06956781
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 15 Mar 2026 to the primary completion date, Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently receiving a behavioral health intervention for concerns related to PTSD or pediatric trauma
Other illness
- Psychiatric concerns requiring a higher level of care (e.g. suicidal ideation with intent; current psychotic disorder)
Other
- An intelligence quotient (IQ) \< 70
- A participating caregiver who is a perpetrator of any identified trauma (e.g. sexual abuse)
- MRI contraindicators (e.g. presence of metal in the body)
Who the study is looking for
- A child between the ages of 8-17 exposed to at least one DSM-defined trauma
- Child assent for participation
- The participation of a caregiver with custodial rights to provide parental permission
- Willing to participate in treatment delivery and respond to surveys
- Meet PTSD diagnostic criteria that is the result of exposure to at least one of the identified traumas
- Ability to read and understand English
- Willingness to be randomized to an experimental condition
- Placement in a stable caregiving environment for two months without an impending transition
- Children currently taking psychotropic medications must have taken the medicine without dose adjustment for two months prior to study entry.
- Caregiver or child with a smartphone capable of downloading a freely available software application.
Age in the registry: 8 years to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Mt. Hope Family Center Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.