NCT06957223Completed
Efficacy of Dextromethorphan-Bupropion Versus SSRIs in the Treatment of Major Depressive Disorder
Efficacy of Dextromethorphan-Bupropion Versus SSRIs in the Treatment of Major Depressive Disorder: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
The study aims to compare the antidepressant effects of a dextromethorphan-bupropion combination versus standard SSRI therapy in adult patients with major depressive disorder. Participants will be randomized into two groups: one receiving dextromethorphan-bupropion and the other receiving an SSRI (e.g., sertraline or escitalopram). Treatment will last for 6 weeks, with assessments at baseline and study completion. The primary outcome will be the remission rate measured by a validated depression rating scale. Secondary outcomes include change in depressive symptoms severity and safety/tolerability measures.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 80 (actual)
- First submitted
- 26 Apr 2025
- Start date
- 6 May 2025
- Primary completion date
- 30 Nov 2025
- Lead sponsor
- Asad Ullah Jan
- Diseases
- Depression
- NCT number
- NCT06957223
What you commit to
- Study type: Interventional
- Participants enrolled: 80
- From 6 May 2025 to the primary completion date, 30 Nov 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of bipolar disorder, schizophrenia, or other psychotic disorders
- Current substance use disorder (within past 6 months)
- Known hypersensitivity to study medications
Other
- Active suicidal ideation requiring urgent intervention
- Pregnancy or breastfeeding
Who the study is looking for
- Diagnosed with major depressive disorder (MDD) per DSM-5 criteria.
- Baseline depression score indicating moderate to severe depression
- Ability to provide informed consent
- Willing to comply with study requirements
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Psychiatry, Combined Military Hospital Nowshera Coordinator of this site? Confirm its status | Nowshera | Pakistan | Unknown status |
| Combined Military Hospital Coordinator of this site? Confirm its status | Nowshera | Pakistan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.