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NCT06960629CompletedPhase 2/3

The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK)

The Effect of Topical Rho-kinase (ROCK) Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy

Source: ClinicalTrials.gov · Last updated 9 Sept 2026

Brief summary (registry, in English)

The goal of this clinical trial is to learn if topical netarsudil/latanoprost works to treat pseudophakic bullous keratopathy in patients with glaucoma. The main questions it aims to answer are: Does topical netarsudil/latanoprost improves visual function in patients with glaucoma and pseudophakic bullous keratopathy? Does topical netarsudil/latanoprost affects the central corneal thickness (CCT) in patients with glaucoma and pseudophakic bullous keratopathy? Researchers will compare topical netarsudil/latanoprost to a placebo (a look-alike substance that contains no drug) to see if topical netarsudil/latanoprost works to treat pseudophakic bullous keratopathy (PBK). Participants will take topical netarsudil/latanoprost or a placebo every day for 12 weeks and visit the clinic once every two weeks for checkups and tests.

Status (registry)
Completed
Phase (registry)
Phase 2/3
Study type
Interventional
Enrollment
50 (actual)
First submitted
28 Apr 2025
Start date
12 May 2025
Primary completion date
1 Apr 2026
Lead sponsor
University Hospital Dubrava
Diseases
Glaucoma
NCT number
NCT06960629

What you commit to

  • Study type: Interventional · Phase 2/3
  • Participants enrolled: 50
  • From 12 May 2025 to the primary completion date, 1 Apr 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • current treatment with topical prostaglandin analogue

Other illness

  • retinal diseases affecting visual acuity

Other

  • other anterior segment pathology (corneal opacities);
  • ocular surface inflammation

Who the study is looking for

  • both sex,
  • age between 40 and 90 years
  • pseudophakic bullous keratopathy
  • glaucoma

Age in the registry: 40 years to 90 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University Hospital Dubrava
Coordinator of this site? Confirm its status
ZagrebCroatiaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.