NCT06966934Recruiting
Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Obesity Patients
The Application of Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Patients With Obesity
Source: ClinicalTrials.gov · Last updated 22 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking cough in patients. Compared with ordinary gastroscopy, painless gastroscopy offers higher comfort and satisfaction for patients and greater convenience for endoscopists during operation. The most common complication of painless gastroscopy diagnosis and treatment is hypoxia. High-flow nasal cannulala (HFNC) provides a higher oxygen concentration and flow rate than an ordinary nasal catheter. It has the functions of heating and humidifying, which can relieve the pressure on the nasal mucosa cilia, keep the airway unobstructed and moist, and reduce the risk of epistaxis. Due to changes in airway anatomical structures such as fat accumulation in the head and neck and hyperplasia of oropharyngeal soft tissues, obese patients are more prone to hypoxia during gastroscopy under sedation. Therefore, HFNC is often used to reduce the occurrence of hypoxia. The nasopharyngeal airway (NPA) is used to maintain the patency of the upper respiratory tract and is suitable for patients with spontaneous breathing but partial obstruction of the upper respiratory tract. It is worth exploring how effective the combination of HFNC and NPA is in improving hypoxemia in obese patients during sedation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 364 (estimated)
- First submitted
- 25 Apr 2025
- Start date
- 14 May 2025
- Primary completion date
- 15 May 2026
- Lead sponsor
- Nanjing First Hospital, Nanjing Medical University
- Diseases
- Obesity
- NCT number
- NCT06966934
What you commit to
- Study type: Interventional
- Planned participants: 364
- From 14 May 2025 to the primary completion date, 15 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients allergic to propofol, eggs, soybeans, milk, etc.;
- Patients with gastrointestinal tract obstruction and gastric emptying disorders;
- Patients with acute pharyngitis, tonsillitis, and upper respiratory tract infections;
- Patients in the acute exacerbation stage of respiratory diseases such as asthma, bronchitis, and chronic obstructive pulmonary disease (COPD);
- Patients with acute arrhythmia and those with severe heart diseases (congenital diseases, valvular diseases);
- Patients with severe hepatic and renal insufficiency who require alternative treatment;
- Patients with severe mental disorders who need medications to control their symptoms;
- Patients with moderate or above anemia, abnormal coagulation function, and hematological diseases;
Other
- Patients with contraindications to endoscopic procedures or those who refuse sedation/anesthesia;
- Patients with nasal cavity lesions leading to severe nasal congestion;
- Pregnant and lactating patients.
Who the study is looking for
- Patients undergoing painless gastroscopy;
- Patients with an age greater than 18 years old;
- American Society of Anesthesiologists (ASA) physical status classification from Grade I to Grade III;
- Body Mass Index (BMI) greater than 28 kg/m²
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nanjing First Hospital Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.