Ischemic Postconditioning in Acute Stroke Patients Receiving Endovascular Thrombectomy

Prior treatment

• The patient is currently enrolled in another investigational drug or device trial.

Other illness

• Adverse events related to thrombectomy, such as contrast extravasation, vascular rupture/perforation, dissection, or embolization to a new territory, detected on post-thrombectomy angiography.
• The patient is febrile (temperature \> 37.5 °C) or has experienced an infection with fever in the last 5 days.
• The patient has a known hypersensitivity or contraindication to aspirin, heparin, Clopidogrel, tirofiban, or sensitivity to contrast media, which cannot be adequately pre-medicated.
• The patient has a known history of bleeding diathesis, coagulopathy, cryoglobulinemia, sickle cell anemia, or will refuse blood transfusions.
• The patient has a pre-AIS life expectancy of \<1 year due to underlying medical conditions or pre-existing co-morbidities.
• The patient is apprehensive about or unwilling to undergo the required MRI imaging at follow-up, has a documented or suspected diagnosis of claustrophobia, or has Gadolinium allergy.
• Other conditions deemed unsuitable for inclusion by the investigator.

Lab values

• The patient has known history of Congestive Heart Failure, hepatic failure, end-stage kidney disease or severe renal failure (clearance \< 30ml/min/1.73m²).

Other

• The interventionalist deems the study device unable to reach the target site.
• Stent placement performed in the M1 segment of the middle cerebral artery or the terminal segment of the internal carotid artery during thrombectomy.
• Angioplasty of more than two cycles of balloon inflation/deflation.
• The patient is experiencing cardiogenic shock, systolic blood pressure \[SBP\] \<100 mmHg, HR\>100 bpm and arterial oxygen saturation (pulse oximetry) \<92% without additional oxygen.
• The patient is a female who is known to be pregnant.

• The patient is ≥ 18 years of age.
• The patient must have symptoms consistent with AIS (i.e. face drooping, arm weakness, speech difficulty, etc.) , with symptoms severity of baseline NIHSS ≥ 6 and beginning less than 24 hours prior to presentation at hospital.
• Pre-stroke mRS ≤ 2.
• Baseline ASPECTS ≥ 6.
• Unilateral middle cerebral artery occlusion, and/or internal carotid artery occlusion.
• The patient is eligible for EVT.
• Successful recanalization achieved through EVT (eTICI 2b-3).
• The patient is willing to provide written informed consent to participate in this clinical trial.