NCT06967935Recruiting
Sleep and Rehearsal-Driven Memory in Epilepsy
Rehearsal-Induced Memory Consolidation and Its Modulation by Sleep in People With Epilepsy
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn "object-place" associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with "wake" and "sleep" condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 5 May 2025
- Start date
- 30 Jun 2025
- Primary completion date
- Jul 2027
- Lead sponsor
- Hospices Civils de Lyon
- Diseases
- Epilepsy
- NCT number
- NCT06967935
What you commit to
- Study type: Observational
- Planned participants: 20
- From 30 Jun 2025 to the primary completion date, Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Major cognitive impairment other than memory deficit
- Persons under psychiatric care
Other
- Refusal to participate
- Pregnant women, women in labor or nursing mothers
- Persons deprived of their liberty by judicial or administrative decision
- Persons admitted to a health or social institution for purposes other than research
- Adults under legal protection (guardianship, curatorship)
Who the study is looking for
- Patient with epilepsy (any type of epilepsy)
- Hospitalized for video-EEG recording lasting at least 4 days
- Aged 18-65 years
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service de neurologie fonctionnelle et d'épileptologie, Hôpital neurologique Pierre Wertheimer Coordinator of this site? Confirm its status | Bron | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.