NCT06968663RecruitingPhase 2
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
Electrical Field Guided Transcranial Magnetic Stimulation to Treat Subacute Post-stroke Aphasia
Source: ClinicalTrials.gov · Last updated 18 Jun 2026
Brief summary (registry, in English)
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke. The main questions this study aims to answer are: 1. Can TMS combined with mCILT improve overall speech? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia. Importantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo MRI scans * Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment * Complete follow-up assessments immediately and 4 months after treatment
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 63 (estimated)
- First submitted
- 5 May 2025
- Start date
- 1 Aug 2024
- Primary completion date
- 31 Jul 2029
- Lead sponsor
- University of Pennsylvania
- Diseases
- Stroke
- NCT number
- NCT06968663
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 63
- From 1 Aug 2024 to the primary completion date, 31 Jul 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous head trauma with loss of consciousness for more than 5 minutes
Other illness
- History of serious and/or ongoing issues with substance abuse
- History of major psychiatric illness
- Dementia, or other neurological conditions
- Epilepsy, or seizure after the stroke event
Other
- Pacemaker
- Diagnosis of tinnitus
- Pregnancy
Who the study is looking for
- Left hemisphere stroke resulting in aphasia
- The stroke must have occurred between 2 and 6 weeks prior to enrollment
- Must be able to understand the nature of the study, and give informed consent
- English proficiency
- Right-handed
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.