NCT06969846Completed
Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
Source: ClinicalTrials.gov · Last updated 14 May 2025
Brief summary (registry, in English)
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies. Directly stimulating the carotid sinus nerve (CSN) is known to potentially reduce blood pressure (BP) but its clinical efficacy has not been consistently demonstrated with existing electrode technologies in humans. We investigated the effect of acute direct CSN stimulation on BP and HR in anesthetized humans using an application-specific multi-contact electrode.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 18 (actual)
- First submitted
- 4 Apr 2025
- Start date
- 3 Apr 2020
- Primary completion date
- 12 Aug 2022
- Lead sponsor
- Louis Stokes VA Medical Center
- Diseases
- High blood pressure
- NCT number
- NCT06969846
What you commit to
- Study type: Interventional
- Participants enrolled: 18
- From 3 Apr 2020 to the primary completion date, 12 Aug 2022
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- prior ipsilateral neck surgery or radiation treatment
Other illness
- history of stroke
- Cardiovascular disease that precluded enrollment were diagnoses which independently increased surgical and anesthetic risk (American Society for Anesthesia Classification System).
Who the study is looking for
- . Eligible patients were those scheduled to undergo elective surgical procedure that therapeutically indicated exposure of the carotid bifurcation and vascular sheath (e.g. carotid endarterectomy, neck dissection, or carotid tumor Resection) regardless of a HTN diagnosis.
Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Northeast Ohio Healthcare System Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.